M
Mitsuru Go
Researcher at Sapporo Medical University
Publications - 31
Citations - 1126
Mitsuru Go is an academic researcher from Sapporo Medical University. The author has contributed to research in topics: Tight junction & Occludin. The author has an hindex of 19, co-authored 31 publications receiving 1034 citations.
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Journal ArticleDOI
HLA-DR- and CD11c-positive dendritic cells penetrate beyond well-developed epithelial tight junctions in human nasal mucosa of allergic rhinitis.
Kenichi Takano,Takashi Kojima,Mitsuru Go,Masaki Murata,Shingo Ichimiya,Tetsuo Himi,Norimasa Sawada +6 more
TL;DR: Results indicate that DCs may easily access antigens beyond epithelial tight junctions in the human nasal mucosa of allergic rhinitis.
Journal ArticleDOI
The role of IL‐33 and its receptor ST2 in human nasal epithelium with allergic rhinitis
TL;DR: The IL‐33 induces T helper 2‐type inflammatory responses and is considered to play a crucial rule in allergic inflammations, such as asthma and atopic dermatitis, but the role of IL‐ 33 and its receptor ST2 in allergic rhinitis remains unknown.
Journal ArticleDOI
Regulation of Tight Junctions in Upper Airway Epithelium
Takashi Kojima,Mitsuru Go,Kenichi Takano,Makoto Kurose,Tsuyoshi Ohkuni,Jun-ichi Koizumi,Ryuta Kamekura,Noriko Ogasawara,Tomoyuki Masaki,Jun Fuchimoto,Kazufumi Obata,Satoshi Hirakawa,Kazuaki Nomura,Takashi Keira,Ryou Miyata,Nobuhiro Fujii,Hiroyuki Tsutsumi,Tetsuo Himi,Norimasa Sawada +18 more
TL;DR: Recent progress in the understanding of the regulation of tight junctions in the upper airway epithelium under normal, allergic, and RSV-infected conditions is summarized.
Journal ArticleDOI
Thymic stromal lymphopoietin enhances tight-junction barrier function of human nasal epithelial cells
Ryuta Kamekura,Takashi Kojima,Jun-ichi Koizumi,Noriko Ogasawara,Makoto Kurose,Mitsuru Go,Atsushi Harimaya,Masaki Murata,Satoshi Tanaka,Hideki Chiba,Tetsuo Himi,Norimasa Sawada +11 more
TL;DR: The nasal-epithelial-derived TSLP thus not only activates DCs but also preserves the epithelial barrier via the upregulation of tight-junction proteins, thereby regulating antigen sensitization during the early stage of allergic rhinitis.
Journal ArticleDOI
Protein Kinase C Enhances Tight Junction Barrier Function of Human Nasal Epithelial Cells in Primary Culture by Transcriptional Regulation
Jun-ichi Koizumi,Takashi Kojima,Noriko Ogasawara,Ryuta Kamekura,Makoto Kurose,Mitsuru Go,Atsushi Harimaya,Masaki Murata,Makoto Osanai,Hideki Chiba,Tetsuo Himi,Norimasa Sawada +11 more
TL;DR: It is suggested that TPA-induced PKC signaling enhances the barrier function of human nasal epithelial cells via transcriptional up-regulation of tight junction proteins, and the mechanisms may contribute to a drug delivery system.