Tsuyoshi Ohkuni

TL;DR: Recent progress in the understanding of the regulation of tight junctions in the upper airway epithelium under normal, allergic, and RSV-infected conditions is summarized.

TL;DR: It is found that the replication of RSV and the epithelial cell responses including induction of tight junctions were regulated via a protein kinase C δ/hypoxia-inducible factor-1α/nuclear factor-κβ pathway, and the control of this pathway may be useful in therapy for RSV-induced respiratory pathogenesis.

TL;DR: It is suggested that JNK may be involved in the regulation of tricellular tight junctions including TRIC expression and the barrier function during normal remodeling of epithelial cells, and prevent disruption of the epithelial barrier in inflammation and other disorders in pancreatic duct epithel cells.

TL;DR: It is suggested that PPAR gamma agonists upregulate the barrier function of tight junctions of human nasal epithelial cells via a PKC signaling pathway and could be novel drugs for protection against inhaled substances and pathogens in the airway epithelium ofhuman nasal mucosa.

TL;DR: The control of TLR3-mediated signaling pathways in HNECs may be important not only in infection by viral dsRNA but also in autoimmune diseases caused by endogenous ds RNA released from necrotic cells.