K
Kazufumi Ohshiro
Researcher at George Washington University
Publications - 51
Citations - 2449
Kazufumi Ohshiro is an academic researcher from George Washington University. The author has contributed to research in topics: Cancer & Internal medicine. The author has an hindex of 25, co-authored 40 publications receiving 2193 citations. Previous affiliations of Kazufumi Ohshiro include Veterans Health Administration & Washington University in St. Louis.
Papers
More filters
Journal ArticleDOI
MicroRNA-7, a Homeobox D10 Target, Inhibits p21-Activated Kinase 1 and Regulates Its Functions
TL;DR: It is established for the first time that Pak1 is a target of microRNA-7 and that HoxD10 plays a regulatory role in modifying the expression of miR- 7 and, consequently, the functions of themiR-7-Pak1 pathway in human cancer cells are established.
Journal ArticleDOI
Pak protein kinases and their role in cancer.
TL;DR: Paks are overexpressed and/or hyperactivated in several human tumors and their role in cell transformation makes them attractive therapeutic targets, and Pak-targeted therapeutics may efficiently inhibit certain types of tumors and efforts to identify selective Pak-inhibitors are underway.
Journal ArticleDOI
Epithelial to mesenchymal transition in head and neck squamous carcinoma: association of Src activation with E-cadherin down-regulation, vimentin expression, and aggressive tumor features.
Mahitosh Mandal,J.N. Myers,Scott M. Lippman,Faye M. Johnson,Michelle D. Williams,Suresh K. Rayala,Kazufumi Ohshiro,David I. Rosenthal,Randal S. Weber,Gary E. Gallick,Adel K. El-Naggar +10 more
TL;DR: The expressions of several factors associated with the induction of EMT in HNSC cell lines and tumor specimens were investigated to define their functional and pathologic role in HnSC.
Journal ArticleDOI
RNA sequencing of cancer reveals novel splicing alterations
Jeyanthy Eswaran,Anelia Horvath,Sucheta Godbole,Sirigiri Divijendra Natha Reddy,Prakriti Mudvari,Kazufumi Ohshiro,Dinesh Cyanam,Sujit S. Nair,Suzanne A. W. Fuqua,Kornelia Polyak,Liliana Florea,Rakesh Kumar +11 more
TL;DR: This study systematically revealed splicing signatures of the three most common types of breast tumors using RNA sequencing and validated the presence of novel hybrid isoforms of critical molecules like CDK4, LARP1, ADD3, and PHLPP2.
Journal ArticleDOI
Insulin-like growth factor receptor as a therapeutic target in head and neck cancer.
Christopher J. Barnes,Kazufumi Ohshiro,Suresh K. Rayala,Adel K. El-Naggar,Rakesh Kumar,Rakesh Kumar +5 more
TL;DR: IGF-IR was overexpression, the functional heterodimerization of IGF-IR and EGFR, and effective therapeutic targeting of these receptors in human head and neck cancer xenografts are found.