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Adel K. El-Naggar

Researcher at University of Texas MD Anderson Cancer Center

Publications -  803
Citations -  60471

Adel K. El-Naggar is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Cancer & Carcinoma. The author has an hindex of 117, co-authored 783 publications receiving 54293 citations. Previous affiliations of Adel K. El-Naggar include University Hospitals of Cleveland & Baylor College of Medicine.

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Comprehensive genomic characterization of head and neck squamous cell carcinomas

Michael S. Lawrence, +309 more
- 29 Jan 2015 - 
TL;DR: It is shown that human-papillomavirus-associated tumours are dominated by helical domain mutations of the oncogene PIK3CA, novel alterations involving loss of TRAF3, and amplification of the cell cycle gene E2F1.
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Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1

Nishant Agrawal, +32 more
- 26 Aug 2011 - 
TL;DR: To explore the genetic origins of head and neck squamous cell carcinoma, whole-exome sequencing and gene copy number analyses were used to study 32 primary tumors and identified mutations in FBXW7 and NotCH1, suggesting that NOTCH1 may function as a tumor suppressor gene rather than an oncogene in this tumor type.
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Pan-cancer analysis of whole genomes

Peter J. Campbell, +1332 more
- 06 Feb 2020 - 
TL;DR: The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.
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Somatic SF3B1 Mutation in Myelodysplasia with Ring Sideroblasts

Elli Papaemmanuil, +51 more
- 12 Oct 2011 - 
TL;DR: Mutations in SF3B1 implicate abnormalities of messenger RNA splicing in the pathogenesis of myelodysplastic syndromes and were associated with down-regulation of key gene networks, including core mitochondrial pathways.
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Nomenclature Revision for Encapsulated Follicular Variant of Papillary Thyroid Carcinoma: A Paradigm Shift to Reduce Overtreatment of Indolent Tumors

Yuri E. Nikiforov, +30 more
- 01 Aug 2016 - 
TL;DR: Thyroid tumors currently diagnosed as noninvasive EFVPTC have a very low risk of adverse outcome and should be termed NIFTP, and this reclassification will affect a large population of patients worldwide and result in a significant reduction in psychological and clinical consequences associated with the diagnosis of cancer.