K
Kazuhiro Takuma
Researcher at Osaka University
Publications - 157
Citations - 7501
Kazuhiro Takuma is an academic researcher from Osaka University. The author has contributed to research in topics: Receptor & Agonist. The author has an hindex of 40, co-authored 147 publications receiving 6717 citations. Previous affiliations of Kazuhiro Takuma include University of Fukui & Columbia University.
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Journal ArticleDOI
ABAD Directly Links Aß to Mitochondrial Toxicity in Alzheimer's Disease
Joyce W. Lustbader,Maurizio Cirilli,Chang Lin,Hongwei Xu,Hongwei Xu,Kazuhiro Takuma,Ning Wang,Casper Caspersen,Xi Chen,Susan Pollak,Michael O. Chaney,Fabrizio Trinchese,Shumin Liu,Frank J. Gunn-Moore,Lih-Fen Lue,Douglas G. Walker,Periannan Kuppusamy,Zay L. Zewier,Ottavio Arancio,David M. Stern,Shirley ShiDu Yan,Hao Wu +21 more
TL;DR: It is demonstrated that Aβ-binding alcohol dehydrogenase (ABAD) is a direct molecular link from Aβ to mitochondrial toxicity and the ABAD-Aβ interaction may be a therapeutic target in Alzheimer's disease.
Journal Article
SEA0400, a Novel and Selective Inhibitor of the Na+-Ca2+ Exchanger, Attenuates Reperfusion Injury in the in Vitro and in Vivo Cerebral Ischemic Models
Toshio Matsuda,Naohisa Arakawa,Kazuhiro Takuma,Yoko Kishida,Yasushi Kawasaki,Masaki Sakaue,Kenzo Takahashi,Teisuke Takahashi,Taizo Suzuki,Tomomi Ota,Akiko Hamano-Takahashi,Michihito Onishi,Yu Tanaka,Kazuya Kameo,Akemichi Baba +14 more
TL;DR: Results indicate that SEA0400 is the most potent and selective inhibitor of NCX, and suggest that the compound may exert protective effects on postischemic brain damage.
Journal ArticleDOI
RAGE-mediated signaling contributes to intraneuronal transport of amyloid-β and neuronal dysfunction
Kazuhiro Takuma,Fang Fang,Wensheng Zhang,Wensheng Zhang,Shiqiang Yan,Shiqiang Yan,Emiko Fukuzaki,Heng Du,Alexander A. Sosunov,Guy M. McKhann,Yoko Funatsu,Noritaka Nakamichi,Taku Nagai,Taku Nagai,Hiroyuki Mizoguchi,Hiroyuki Mizoguchi,Daisuke Ibi,Daisuke Ibi,Osamu Hori,Satoshi Ogawa,David M. Stern,Kiyofumi Yamada,Kiyofumi Yamada,Shirley ShiDu Yan +23 more
TL;DR: It is demonstrated that receptor for advanced glycation end products (RAGE) contributes to transport of Aβ from the cell surface to the intracellular space, thereby enhancing Aβ cytotoxicity.
Journal ArticleDOI
ABAD enhances Aβ-induced cell stress via mitochondrial dysfunction
Kazuhiro Takuma,Jun Yao,Jianmin Huang,Hongwei Xu,Xi Chen,John S. Luddy,Anne-Cecile Trillat,David M. Stern,Ottavio Arancio,Ottavio Arancio,Shirley ShiDu Yan +10 more
TL;DR: Findings link ABAD‐induced oxidant stress to critical aspects of Alzheimer's disease (AD)‐associated cellular dysfunction, suggesting a pivotal role for this enzyme in the pathogenesis of AD.
Journal ArticleDOI
Autism-like behaviours with transient histone hyperacetylation in mice treated prenatally with valproic acid.
Shunsuke Kataoka,Kazuhiro Takuma,Yuta Hara,Yuko Maeda,Yukio Ago,Toshio Matsuda,Toshio Matsuda +6 more
TL;DR: It is suggested that VPA-induced histone hyperacetylation plays a key role in cortical pathology and abnormal autism-like behaviours in mice.