Kazuhiro Tateda

TL;DR: In this paper, the authors reported that mouse macrophages restricted Legionella pneumophila replication and initiated a proinfl ammatory program of cell death when fl agellin contaminated their cytosol.

TL;DR: The data suggest that the quorum-sensing molecule 3-oxo-C12-HSL has critical roles in the pathogenesis of P. aeruginosa infection, not only in the induction of bacterial virulence factors but also in the modulation of host responses.

TL;DR: It is suggested that oral administration of phage may be effective against gut-derived sepsis caused by P. aeruginosa, and the levels of inflammatory cytokines in blood and liver were significantly lower inphage-treated mice than in phage-untreated mice.

TL;DR: It is indicated that the azithromycin treatment in vivo results in significant reduction in airway-specific inflammation, which occurs in part by inhibition of neutrophil recruitment to the lung through reduction in proinflammatory cytokine expression and inhibition ofNeutrophil migration via the extracellular signal-regulated kinase-1 and -2 signal transduction pathway.

TL;DR: Data suggest that colistin may be an important option for combination therapy against critical MDRP infections, especially for pneumonia especially, and not only for synergistic antibacterial activity, but also for blocking LPS.