K
Kazuki Nakajima
Researcher at Fujita Health University
Publications - 49
Citations - 1149
Kazuki Nakajima is an academic researcher from Fujita Health University. The author has contributed to research in topics: Glycan & Glycosylation. The author has an hindex of 21, co-authored 47 publications receiving 958 citations. Previous affiliations of Kazuki Nakajima include National Institute of Advanced Industrial Science and Technology & RIKEN Brain Science Institute.
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Journal ArticleDOI
Simultaneous determination of nucleotide sugars with ion-pair reversed-phase HPLC
Kazuki Nakajima,Shinobu Kitazume,Takashi Angata,Reiko Fujinawa,Kazuaki Ohtsubo,Eiji Miyoshi,Naoyuki Taniguchi +6 more
TL;DR: A conventional HPLC method for simultaneous determination of nucleotide sugars was applied to characterize nucleotide sugar levels in breast and pancreatic cancer cell lines and revealed that the abundance of UDP-GlcNAc, UDP-GalNAc , UDP-glcUA and GDP-Fuc were a cell-type-specific feature.
Journal ArticleDOI
Glucocerebrosidase deficiency accelerates the accumulation of proteinase K-resistant α-synuclein and aggravates neurodegeneration in a Drosophila model of Parkinson's disease
Mari Suzuki,Nobuhiro Fujikake,Toshihide Takeuchi,Ayako Kohyama-Koganeya,Kazuki Nakajima,Yoshio Hirabayashi,Keiji Wada,Yoshitaka Nagai +7 more
TL;DR: The findings suggest that the functional loss of GCase or β-Gal promotes the toxic conversion of αSyn via aberrant interactions between αSyn and their substrate glycolipids, leading to the aggravation of α synuclein-mediated neurodegeneration.
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Hypoxic regulation of glycosylation via the N-acetylglucosamine cycle.
Ken Shirato,Kazuki Nakajima,Hiroaki Korekane,Shinji Takamatsu,Congxiao Gao,Takashi Angata,Kazuaki Ohtsubo,Naoyuki Taniguchi +7 more
TL;DR: Current thinking of how hypoxia alters glucose metabolic fluxes that can modulate cellular glycosylation patterns and consequently modify cellular functions is discussed, particularly from the standpoint of the N-acetylglucosamine cycle, a part of the ”Glycan cycle”.
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Elevated O-GlcNAcylation promotes colonic inflammation and tumorigenesis by modulating NF-κB signaling
Yong Ryoul Yang,Dae Hyun Kim,Young Kyo Seo,Dohyun Park,Hyun Jun Jang,Hyun Jun Jang,Soo Youn Choi,Yong Hwa Lee,Gyun Hui Lee,Kazuki Nakajima,Naoyuki Taniguchi,Jung-Min Kim,Eun Jeong Choi,Hyo Youl Moon,Il Shin Kim,Jang Hyun Choi,Ho Lee,Sung Ho Ryu,Lucio Cocco,Pann-Ghill Suh +19 more
TL;DR: The results suggest that the elevated O-GlcNAcylation level in colonic tissues contributes to the development of colitis and CAC by disrupting regulation of NF-κB-dependent transcriptional activity.
Journal ArticleDOI
A new fungal lectin recognizing α(1-6)-linked fucose in the N-glycan
Yasuo Oda,Tsutomu Senaha,Yuuki Matsuno,Kazuki Nakajima,Ryousuke Naka,Mitsuhiro Kinoshita,Eiko Honda,Itaru Furuta,Kazuaki Kakehi +8 more
TL;DR: Capillary affinity electrophoresis studies indicated that RSL binds strongly to N-glycans with α(1–6)-linked fucose residues, which could make RSL a valuable tool for glycobiological studies.