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Shinobu Kitazume
Researcher at Fukushima Medical University
Publications - 93
Citations - 3205
Shinobu Kitazume is an academic researcher from Fukushima Medical University. The author has contributed to research in topics: Amyloid precursor protein & Glycosylation. The author has an hindex of 27, co-authored 86 publications receiving 2736 citations. Previous affiliations of Shinobu Kitazume include Max Planck Society.
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Journal ArticleDOI
Functional roles of N-glycans in cell signaling and cell adhesion in cancer.
Yanyang Zhao,Motoko Takahashi,Jianguo Gu,Eiji Miyoshi,Akio Matsumoto,Shinobu Kitazume,Naoyuki Taniguchi +6 more
TL;DR: It is suggested that the modulation of N‐glycans of those receptors alters their important functions such as cell signaling and cell adhesion which are implicated in cancer invasion and metastasis.
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Alzheimer's β-secretase, β-site amyloid precursor protein-cleaving enzyme, is responsible for cleavage secretion of a Golgi-resident sialyltransferase
Shinobu Kitazume,Yuriko Tachida,Ritsuko Oka,Keiro Shirotani,Takaomi C. Saido,Yasuhiro Hashimoto +5 more
TL;DR: BACE1 is responsible for the cleavage and secretion of ST6Gal I, a sialyltransferase that produces a sIALylα2,6galactose residue, and the enzyme is secreted out of the cell after proteolytic cleavage.
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An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease
Yasuhiko Kizuka,Shinobu Kitazume,Reiko Fujinawa,Takashi Saito,Nobuhisa Iwata,Nobuhisa Iwata,Takaomi C. Saido,Miyako Nakano,Yoshiki Yamaguchi,Yasuhiro Hashimoto,Matthias Staufenbiel,Hiroyuki Hatsuta,Shigeo Murayama,Hiroshi Manya,Tamao Endo,Naoyuki Taniguchi +15 more
TL;DR: Analysis of knockout mice lacking the biosynthetic enzyme for bisecting GlcNAc, GnT‐III (Mgat3), revealed that cleavage of Aβ‐precursor protein (APP) by BACE1 is reduced in these mice, resulting in a decrease in Aβ plaques and improved cognitive function.
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Simultaneous determination of nucleotide sugars with ion-pair reversed-phase HPLC
Kazuki Nakajima,Shinobu Kitazume,Takashi Angata,Reiko Fujinawa,Kazuaki Ohtsubo,Eiji Miyoshi,Naoyuki Taniguchi +6 more
TL;DR: A conventional HPLC method for simultaneous determination of nucleotide sugars was applied to characterize nucleotide sugar levels in breast and pancreatic cancer cell lines and revealed that the abundance of UDP-GlcNAc, UDP-GalNAc , UDP-glcUA and GDP-Fuc were a cell-type-specific feature.
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Characterization of α2,6-Sialyltransferase Cleavage by Alzheimer's β-Secretase (BACE1)
Shinobu Kitazume,Yuriko Tachida,Ritsuko Oka,Norihiro Kotani,Kazuko Ogawa,Minoru Suzuki,Naoshi Dohmae,Koji Takio,Takaomi C. Saido,Yasuhiro Hashimoto +9 more
TL;DR: The results suggest that ST6Gal I is cleaved initially between Leu37 and Gln38 by BACE1, and then the three-amino acid sequence at the NH2 terminus is removed by exopeptidase(s) before secretion from the cells.