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Congxiao Gao
Researcher at Osaka University
Publications - 27
Citations - 1093
Congxiao Gao is an academic researcher from Osaka University. The author has contributed to research in topics: COPD & Exacerbation. The author has an hindex of 16, co-authored 27 publications receiving 984 citations.
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Journal ArticleDOI
Purification and cDNA cloning of porcine brain GDP-L-Fuc : N-acetyl-beta-D-glucosaminide alpha1->6fucosyltransferase
Naofumi Uozumi,Shusaku Yanagidani,Eiji Miyoshi,Yoshito Ihara,Takahiko Sakuma,Congxiao Gao,Tadashi Teshima,Shigeru Fujii,Tetsuo Shiba,Naoyuki Taniguchi +9 more
TL;DR: Northern blotting analyses of rat adult tissues showed that α1-6FucT was highly expressed in brain, and no sequence homology was found with other previously cloned fucosyl transferases, but the enzyme appears to be a type II transmembrane protein like the other glycosyltransferases.
Journal ArticleDOI
Gene expression of α1‐6 fucosyltransferase in human hepatoma tissues: A possible implication for increased fucosylation of α‐fetoprotein
Katsuhisa Noda,Eiji Miyoshi,Naofumi Uozumi,Shusaku Yanagidani,Yoshitaka Ikeda,Congxiao Gao,Kunio Suzuki,Harumasa Yoshihara,Masumi Yoshikawa,Kiyoshi Kawano,Norio Hayashi,Masatsugu Hori,Naoyuki Taniguchi +12 more
TL;DR: It is suggested that the enhancement of α1‐6 FucT expression increased the fucosylation of several proteins, including AFP, and that the level of α 1‐6–fucosyated AFP in patients with HCC was in part caused by up‐regulation of the α1 •fucT gene expression.
Journal Article
Relationship between Elevated FX Expression and Increased Production of GDP-l-Fucose, a Common Donor Substrate for Fucosylation in Human Hepatocellular Carcinoma and Hepatoma Cell Lines
Katsuhisa Noda,Eiji Miyoshi,Jianguo Gu,Congxiao Gao,Susumu Nakahara,Takatoshi Kitada,Koichi Honke,Kunio Suzuki,Harumasa Yoshihara,Kiyoshi Yoshikawa,Kiyoshi Kawano,Michela Tonetti,Akinori Kasahara,Masatsugu Hori,Norio Hayashi,Naoyuki Taniguchi +15 more
TL;DR: The results herein suggest that the high level of fucosylation in HCC is dependent on a high expression of FX followed by increases in GDP-L-fucose, as well as an enhancement in alpha1-6 FucT expression.
Journal ArticleDOI
A Single Dose of Lipopolysaccharide into Mice with Emphysema Mimics Human Chronic Obstructive Pulmonary Disease Exacerbation as Assessed by Micro-Computed Tomography
Satoshi Kobayashi,Reiko Fujinawa,Fumi Ota,Shiho Kobayashi,Takashi Angata,Manabu Ueno,Toshitaka Maeno,Shinobu Kitazume,Keiichi Yoshida,Takeo Ishii,Congxiao Gao,Kazuaki Ohtsubo,Yoshiki Yamaguchi,Tomoko Betsuyaku,Kozui Kida,Naoyuki Taniguchi +15 more
TL;DR: A simple mouse model of COPD exacerbation that mimics human cases to some extent and will be useful for elucidating its mechanism and developing therapeutic strategies is used.
Journal ArticleDOI
A fluorescent assay method for GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha 1-6fucosyltransferase activity, involving high performance liquid chromatography.
Naofumi Uozumi,Tadashi Teshima,Toshihiro Yamamoto,Atsushi Nishikawa,Yu-E Gao,Eiji Miyoshi,Congxiao Gao,Katsuhisa Noda,Kazi Nazrul Islam,Yoshito Ihara,Shigeru Fujii,Tetsuo Shiba,Naoyuki Taniguchi +12 more
TL;DR: An assay method for GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha 1-6fucosyltransferase (alpha 1- 6FucT; EC 2.4.1.68) activity has been developed, involving a fluorescent pyridylaminated substrate, and is applicable for various experiments, including purification and cell culture ones.