K
Kazunari Taira
Researcher at Japanese Ministry of International Trade and Industry
Publications - 48
Citations - 3239
Kazunari Taira is an academic researcher from Japanese Ministry of International Trade and Industry. The author has contributed to research in topics: Ribozyme & RNA. The author has an hindex of 27, co-authored 48 publications receiving 3197 citations. Previous affiliations of Kazunari Taira include National Institute of Advanced Industrial Science and Technology & University of Tsukuba.
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U6 promoter-driven siRNAs with four uridine 3' overhangs efficiently suppress targeted gene expression in mammalian cells
TL;DR: A vector-based siRNA expression system that can induce RNAi in mammalian cells is reported, which might allow therapeutic applications by means of vector-mediated RNAi and facilitate a wide range of functional analysis of mammalian genes.
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Analysis of bph operon from the polychlorinated biphenyl-degrading strain of Pseudomonas pseudoalcaligenes KF707.
TL;DR: The biphenyl degradation pathway and the responsible enzymes/genes are very similar to those of toluene degradation despite their discrete substrate specificity.
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A Novel Allosterically trans-Activated Ribozyme, the Maxizyme, with Exceptional Specificity In Vitro and In Vivo
Tomoko Kuwabara,Tomoko Kuwabara,Masaki Warashina,Masaki Warashina,Tsuyoshi Tanabe,Kenzaburo Tani,Shigetaka Asano,Kazunari Taira,Kazunari Taira +8 more
TL;DR: An allosterically controllable novel enzyme that can be transcribed in vivo under the control of a human tRNA(Val) promoter that had extremely high specificity and high-level activity, not only in vitro but also in cultured cells including BV173 cells derived from a patient with a Philadelphia chromosome.
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Cloning and nucleotide sequence of the 2,3-dihydroxybiphenyl dioxygenase gene from the PCB-degrading strain of Pseudomonas paucimobilis Q1
Kazunari Taira,Nobuki Hayase,Nariaki Arimura,Shigeki Yamashita,Miyazaki Toshitsugu,Kensuke Furukawa +5 more
TL;DR: The bphC gene encoding 2,3-dihydroxybiphenyl dioxygenase was cloned from biphenyl-degrading and chlorinated biphenYL-degRading Pseudomonas paucimobilis Q1, and its complete nucleotide sequence was determined.
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A novel RNA motif that binds efficiently and specifically to the Ttat protein of HIV and inhibits the trans-activation by Tat of transcription in vitro and in vivo.
Rika Yamamoto,Masato Katahira,Satoshi Nishikawa,Tadashi Baba,Kazunari Taira,Kazunari Taira,Penmetcha K. R. Kumar +6 more
TL;DR: Various properties of aptamer RNATat, a 37‐mer RNA oligomer, including binding kinetics, identification of functional groups for Tat binding, and inhibition of Tat function are analysed.