Tadashi Baba

TL;DR: It is shown that CoREST endows LSD1 with the ability to demethylate nucleosomal substrates and that it protects LSD1 from proteasomal degradation in vivo, suggesting that hypoacetylated nucleosomes may be the preferred physiological substrate.

TL;DR: In livers from GLD-2-null mice, the steady-state level of the mature form of miR-122 was specifically lower than in heterozygous mice, whereas no reduction of pre-miR- 122 was observed, demonstrating that 3'-terminal adenylation by GLd-2 is required for the selective stabilization of mi R-122 in the liver.

TL;DR: In vitro fertilization assays verified that sperm from the homozygous mutant mice penetrate the zona pellucida and effect fertilization, showing that acrosin is not essential for both sperm penetration of the zzon pellUCida and fertilization.

TL;DR: A mouse testis cDNA encoded a 655-residue protein, designated PC4, containing a bacterial subtilisin-like catalytic domain closely related to those of the recently characterized precursor-processing endoproteases, furin, PC1/PC3, PC2, and Kex2.

TL;DR: It is concluded that formation of the abnormal branched glucans in the amylose-extender mutant of rice is due to the lack of the RBE3 activity, which belongs to a family of theAmylolytic enzymes.