Kazunari Yamaguchi

TL;DR: Monoclonal Integration of the HTLV provirus genome in all primary tumor cells of ATL not only indicates that HTLV directly interacts with target cells, which become leukemic, and that integration of the prov virus genome is a prerequisite for development of ATL and possibly other related diseases but also indicates that the virus is not associated with other types of lymphoma or leukemia.

TL;DR: Data indicate that HTLV‐I causes a specific type of intraocular inflammation, uveitis, which is characterized clinically by a moderate inflammation of the vitreous body accompanied by a mild iritis and retinal vasculitis.

TL;DR: The high frequency of this defective virus in the aggressive form of ATL suggests that it may be caused by the genetic instability of HTLV-I provirus, and cells with this defectiveirus are selected because they escape from immune surveillance systems.

TL;DR: Adult T-cell leukemia (ATL) was first reported in Japan, where it has a high incidence in the southwestern region, and the retrovirus, human T-lymphotropic virus type I (HTLV-I), is found to be the causative agent.

TL;DR: Hypermethylation of the 5′ LTR appears to be an important mechanism by which HTLV-1 gene expression is repressed during viral latency, and the observation that proviral gene Expression is reactivated by 5-azacytidine in latently infected cell lines indicates that selective hypermethylation is common both in vivo and in vitro.