K
Kazunori Murata
Researcher at Johns Hopkins University
Publications - 7
Citations - 438
Kazunori Murata is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Complement system & Antibody. The author has an hindex of 7, co-authored 7 publications receiving 405 citations.
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Journal ArticleDOI
Mechanisms of complement activation, C4d deposition, and their contribution to the pathogenesis of antibody-mediated rejection.
TL;DR: The rationale for the use of C4d as a marker of antibody-mediated rejection, along with the clinical evidence supporting its use, are summarized and mechanisms by which C4D can be activated by the classical and lectin pathways of complement activation are identified.
Journal ArticleDOI
In Vivo Platelet–Endothelial Cell Interactions in Response to Major Histocompatibility Complex Alloantibody
Craig N. Morrell,Kazunori Murata,Anne Marie Swaim,Emily Mason,Tanika V. Martin,Laura E. Thompson,Mathew Ballard,Karen Fox-Talbot,Barbara A. Wasowska,William M. Baldwin +9 more
TL;DR: It is demonstrated using a skin transplant model that alloantibody indirectly induces platelet activation and rolling in vivo and that platelets recruit leukocytes to sites of alloantsibody deposition and sustain leukocyte–endothelial cell interactions in vivo.
Journal ArticleDOI
Synergistic deposition of C4d by complement-activating and non-activating antibodies in cardiac transplants.
Kazunori Murata,Karen Fox-Talbot,Zhiping Qian,Kazue Takahashi,Gregory L. Stahl,William M. Baldwin,Barbara A. Wasowska +6 more
TL;DR: A novel role for non‐complement‐activating alloantibodies and MBL in humoral rejection is suggested, as demonstrated in mice reconstituted with monoclonal antibodies to MHC class I antigens.
Journal ArticleDOI
C4d deposition and clearance in cardiac transplants correlates with alloantibody levels and rejection in rats.
K. Minami,Kazunori Murata,Chih Yuan Lee,Karen Fox-Talbot,Barbara A. Wasowska,Mark D. Pescovitz,William M. Baldwin +6 more
TL;DR: C4d deposition is not limited to the capillaries, but extends throughout the arterial tree, and despite formation of a covalent bond, C4d is cleared within days.
Journal ArticleDOI
The involvement of FcR mechanisms in antibody-mediated rejection.
Chih Yuan Lee,Chih Yuan Lee,Sahar Lotfi-Emran,Melek M. Erdinc,Kazunori Murata,Ergun Velidedeoglu,Karen Fox-Talbot,Jinhuan Liu,Justin W. Garyu,William M. Baldwin,Barbara A. Wasowska +10 more
TL;DR: It is indicated that IgG1 Allo-mAbs to major histocompatibility complex class I antigens can augment graft injury by stimulating EC to produce MCP-1 and by activating mononuclear cells through their Fc receptors.