In Vivo Platelet–Endothelial Cell Interactions in Response to Major Histocompatibility Complex Alloantibody
Craig N. Morrell,Kazunori Murata,Anne Marie Swaim,Emily Mason,Tanika V. Martin,Laura E. Thompson,Mathew Ballard,Karen Fox-Talbot,Barbara A. Wasowska,William M. Baldwin +9 more
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TLDR
It is demonstrated using a skin transplant model that alloantibody indirectly induces platelet activation and rolling in vivo and that platelets recruit leukocytes to sites of alloantsibody deposition and sustain leukocyte–endothelial cell interactions in vivo.Abstract:
Platelets recruit leukocytes and mediate interactions between leukocytes and endothelial cells. Most studies examining this important platelet immune function have focused on the development of atherosclerosis, but similar mechanisms may contribute to acute and chronic vascular lesions in transplants. Platelets have been described as markers of transplant rejection, but little investigation has critically examined a role for platelets in transplant vasculopathy and, in particular, alloantibody-mediated transplant rejection. We now demonstrate using a skin transplant model that alloantibody indirectly induces platelet activation and rolling in vivo. Repeated IgG2a alloantibody injections result in sustained platelet-endothelial interactions and vascular pathology, including von Willebrand factor release, small platelet thrombi, and complement deposition. Maintenance of continued platelet-endothelial interactions are dependent on complement activation. Furthermore, we demonstrate that platelets recruit leukocytes to sites of alloantibody deposition and sustain leukocyte-endothelial cell interactions in vivo. Taken together, our model demonstrates an important role for platelets in alloantibody induced transplant rejection.read more
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Banff '09 meeting report: Antibody mediated graft deterioration and implementation of Banff working groups
Banu Sis,Michael Mengel,Mark Haas,Robert B. Colvin,Philip F. Halloran,Lorraine C. Racusen,Kim Solez,William M. Baldwin,Erika Bracamonte,V. Broecker,Fernando G. Cosio,Anthony J. Demetris,Cinthia B. Drachenberg,Gunilla Einecke,James M. Gloor,Denis Glotz,Edward S. Kraus,Christophe Legendre,Helen Liapis,Roslyn B. Mannon,Brian J. Nankivell,Volker Nickeleit,John C. Papadimitriou,Parmjeet Randhawa,Heinz Regele,Karine Renaudin,E. R. Rodriguez,Daniel Serón,Surya V. Seshan,Manikkam Suthanthiran,Barbara A. Wasowska,Andrea A. Zachary,A. Zeevi +32 more
TL;DR: The willingness of the Banff process to adapt continuously in response to new research and improve potential weaknesses, led to the implementation of six working groups on the following areas: isolated v‐lesion, fibrosis scoring, glomerular lesions, molecular pathology, polyomavirus nephropathy and quality assurance.
Journal ArticleDOI
Platelets, inflammation and tissue regeneration
TL;DR: They are major players in atherosclerosis and related diseases, pathologies of the central nervous system (Alzheimers disease, multiple sclerosis), cancer and tumour growth, and participate in other tissue-related acquired pathologies such as skin diseases and allergy, rheumatoid arthritis, liver disease; while, paradoxically, autologous platelet-rich plasma and platelet releasate are being used as an aid to promote tissue repair and cellular growth.
Journal ArticleDOI
Platelet functions beyond hemostasis
Susan S. Smyth,Rodger P. McEver,Andrew S. Weyrich,C. N. Morrell,Maureane Hoffman,Gowthami M. Arepally,Patricia A. French,Harold L. Dauerman,Richard C. Becker +8 more
TL;DR: The process of and factors mediating platelet–platelet and platelet-leukocyte interactions in inflammatory and immune responses are discussed, with the roles of P‐selectin, chemokines and Src family kinases being highlighted.
Journal ArticleDOI
Report from a consensus conference on antibody-mediated rejection in heart transplantation
Jon A. Kobashigawa,María G. Crespo-Leiro,Stephan M. Ensminger,Hermann Reichenspurner,Annalisa Angelini,Gerald J. Berry,Margaret Burke,Lawrence S.C. Czer,Nicola E. Hiemann,Abdallah G. Kfoury,Donna Mancini,Paul Mohacsi,Jignesh Patel,Naveen L. Pereira,Jeffrey L. Platt,Elaine F. Reed,Nancy L. Reinsmoen,E. Rene Rodriguez,Marlene L. Rose,Stuart D. Russell,Randy Starling,Nicole Suciu-Foca,Jose A. Tallaj,David O. Taylor,Adrian B. Van Bakel,Lori J. West,Adriana Zeevi,Andreas Zuckermann +27 more
TL;DR: A clinical definition for AMR (cardiac dysfunction and/or circulating donor-specific antibody) was no longer believed to be required due to recent publications demonstrating that asymptomatic (no cardiac dysfunction) biopsy-proven AMR is associated with subsequent greater mortality and greater development of cardiac allograft vasculopathy.
Journal ArticleDOI
Platelets as Cellular Effectors of Inflammation in Vascular Diseases
TL;DR: Recently identified inflammatory and immune activities provide insights into the biology of these versatile blood cells that are directly relevant to human vascular diseases.
References
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TL;DR: This Review highlights the molecular machinery and inflammatory pathways used by platelets to initiate and accelerate atherothrombosis.
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Circulating activated platelets exacerbate atherosclerosis in mice deficient in apolipoprotein E
Yuqing Huo,Andreas Schober,S. Bradley Forlow,David F. Smith,Matthew C. Hyman,Steffen Jung,Dan R. Littman,Christian Weber,Klaus Ley +8 more
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P-selectin glycoprotein ligand-1 mediates rolling of human neutrophils on P-selectin.
Kevin L. Moore,K D Patel,Richard E. Bruehl,Fugang Li,D A Johnson,H.S. Lichenstein,Richard D. Cummings,D F Bainton,Rodger P. McEver +8 more
TL;DR: Data indicate thatPSGL-1 accounts for the high affinity binding sites for P-selectin on leukocytes, and PSGL- 1 must interact with P- Selectin in order for neutrophils to roll on P- selectin at physiological shear stresses.
Journal ArticleDOI
RANTES Deposition by Platelets Triggers Monocyte Arrest on Inflamed and Atherosclerotic Endothelium
Philipp von Hundelshausen,Philipp von Hundelshausen,Philipp von Hundelshausen,Kim S. C. Weber,Kim S. C. Weber,Kim S. C. Weber,Yuqing Huo,Yuqing Huo,Yuqing Huo,Amanda E. I. Proudfoot,Amanda E. I. Proudfoot,Amanda E. I. Proudfoot,Peter J. Nelson,Peter J. Nelson,Peter J. Nelson,Klaus Ley,Klaus Ley,Klaus Ley,Christian Weber +18 more
TL;DR: The deposition of RANTES by platelets triggers shear-resistant monocyte arrest on inflamed or atherosclerotic endothelium and may epitomize a novel principle relevant to inflammatory or atherogenic monocyte recruitment from the circulation.
Journal ArticleDOI
Platelets in Inflammation and Thrombosis
Denisa D. Wagner,Peter C. Burger +1 more
TL;DR: This review will give a short overview of work stemming from the laboratory showing that thrombosis and inflammation share several key molecular mechanisms and in fact are 2 intrinsically linked processes.
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