K
Kazuya Sato
Researcher at Jichi Medical University
Publications - 83
Citations - 1843
Kazuya Sato is an academic researcher from Jichi Medical University. The author has contributed to research in topics: Transplantation & Hematopoietic stem cell transplantation. The author has an hindex of 16, co-authored 83 publications receiving 1619 citations.
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Journal ArticleDOI
Nitric oxide plays a critical role in suppression of T-cell proliferation by mesenchymal stem cells.
Kazuya Sato,Katsutoshi Ozaki,Iekuni Oh,Akiko Meguro,Keiko Hatanaka,Tadashi Nagai,Kazuo Muroi,Keiya Ozawa +7 more
TL;DR: It is found that Stat5 phosphorylation in T cells is suppressed in the presence of MSCs and that nitric oxide (NO) is involved in the suppression of Stat5osphorylation and T-cell proliferation, and that NO produced by Mscs is one of the major mediators of T- cell suppression by M SCs.
Journal ArticleDOI
Mesenchymal stromal cells for graft-versus-host disease : basic aspects and clinical outcomes.
TL;DR: In this article, the authors focus on basic aspects of MSC-mediated T cell suppression and clinical trials using MSCs for graft-versus-leukemia and related conditions.
Journal ArticleDOI
Mesenchymal stromal cells inhibit Th17 but not regulatory T-cell differentiation
Raine Tatara,Katsutoshi Ozaki,Yuji Kikuchi,Keiko Hatanaka,Iekuni Oh,Akiko Meguro,Haruko Matsu,Kazuya Sato,Keiya Ozawa +8 more
TL;DR: The results suggest that MSC regulate CD4 differentiation through different mechanisms depending on the culture conditions, suggesting that M SC suppress Th17 differentiation at least in part through PGE2 and IDO.
Journal ArticleDOI
Prognostic impact of extranodal involvement in diffuse large B-cell lymphoma in the rituximab era†
Hiroyuki Takahashi,Naoto Tomita,Masahiro Yokoyama,Saburo Tsunoda,Takahiro Yano,Kayoko Murayama,Chizuko Hashimoto,Kazuo Tamura,Kazuya Sato,Yoshiaki Ishigatsubo +9 more
TL;DR: Extranodal involvement is considered a poor prognostic factor for patients with diffuse large B‐cell lymphoma (DLBCL); however, the prognostic impact of specific sites of involvement has not been fully elucidated.
Journal ArticleDOI
Central nervous system event in patients with diffuse large B-cell lymphoma in the rituximab era
Naoto Tomita,Masahiro Yokoyama,Wataru Yamamoto,Reina Watanabe,Yutaka Shimazu,Yasufumi Masaki,Saburo Tsunoda,Chizuko Hashimoto,Kayoko Murayama,Takahiro Yano,Rumiko Okamoto,Ako Kikuchi,Kazuo Tamura,Kazuya Sato,Kazutaka Sunami,Hirohiko Shibayama,Rishu Takimoto,Rika Ohshima,Yoshihiro Hatta,Yukiyoshi Moriuchi,Tomohiro Kinoshita,Masahide Yamamoto,Ayumi Numata,Yoshiaki Ishigatsubo,Kengo Takeuchi +24 more
TL;DR: Patients with testicular involvement, involvement of breast, adrenal gland, and bone are identified as independent risk factors for central nervous system (CNS) events in patients with diffuse large B‐cell lymphoma in the rituximab era and it is concluded that patients with these risk factors are at high risk for CNS events.