Haruko Matsu

TL;DR: The results suggest that MSC regulate CD4 differentiation through different mechanisms depending on the culture conditions, suggesting that M SC suppress Th17 differentiation at least in part through PGE2 and IDO.

TL;DR: Three-year PFS with R-70%CHOP for patients aged 70 years and older was not significantly worse than that with full-dose R-CHop for younger patients, suggesting that R- 70% CHOP might be a reasonable choice for patients with DLBCL aged 70 year and older, especially for those with comorbidities.

TL;DR: It is demonstrated that morbidity and mortality of GVHD was significantly reduced after BMT with splenocytes from IL-21R−/− mice compared with those from wild type mice, and that blockade of the IL- 21 signal may represent a novel strategy for the prophylaxis for GV HD.

TL;DR: It is found that CD25 depletion altered neither the impaired MLR in vitro nor the ameliorated GVHD symptoms in vivo, suggesting that the attenuated GV HD might be caused by an impairment of effector T cell differentiation itself, rather than by an increase in regulatory T cells and suppression of effectors T cells.

TL;DR: It is found that Cotransplantation with CD8-depleted splenocytes but not with purified CD8 T-cells resulted in a significant reduction in anti-leukemic effect of IL-21R−/− cells compared with wild-type cells, suggesting the retention of GVL effects in the absence ofIL-21 signaling.