K
Kazuyuki Ohbo
Researcher at European Bioinformatics Institute
Publications - 5
Citations - 1597
Kazuyuki Ohbo is an academic researcher from European Bioinformatics Institute. The author has contributed to research in topics: Oct-4 & Cellular differentiation. The author has an hindex of 5, co-authored 5 publications receiving 1543 citations. Previous affiliations of Kazuyuki Ohbo include National Institutes of Health & Kumamoto University.
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Journal ArticleDOI
Germline regulatory element of Oct-4 specific for the totipotent cycle of embryonal cells
Young Il Yeom,Guy Fuhrmann,Catherine E. Ovitt,Alexander Brehm,Kazuyuki Ohbo,Michael K. Gross,Karin Hübner,Hans R. Schöler +7 more
TL;DR: Oct-4 expression in the germline is regulated separately from epiblast expression, and this provides the first marker for the identification of totipotent cells in the embryo, and suggests that expression of Oct-4 in the Totipotent cycle is dependent on a set of factors unique to the germ line.
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Germline-specific expression of the Oct-4/green fluorescent protein (GFP) transgene in mice.
Tomomi Yoshimizu,Noriyuki Sugiyama,Mario De Felice,Mario De Felice,Young Ii Yeom,Young Ii Yeom,Kazuyuki Ohbo,Kazuyuki Ohbo,Kazue Masuko,Masuo Obinata,Kuniya Abe,Hans R. Schöler,Yasuhisa Matsui +12 more
TL;DR: These transgenic mice proved to be powerful tools for isolating living germ cells at various developmental stages to study their nature and to isolate new genes.
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The carboxy-terminal transactivation domain of Oct-4 acquires cell specificity through the POU domain.
TL;DR: Phosphopeptide analysis revealed that the cell-type-specific difference of C-domain activity correlates with a difference in Oct-4 phosphorylation status, suggesting an additional regulatory mechanism for determiningOct-4 function in rapidly changing cell types during development.
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Retinoic acid-mediated down-regulation of Oct3/4 coincides with the loss of promoter occupancy in vivo.
Saverio Minucci,Valérie Botquin,Young Il Yeom,Anup Dey,Ian Sylvester,Dina J. Zand,Kazuyuki Ohbo,Keiko Ozato,Hans R. Schöler +8 more
TL;DR: The partial factor displacement seen in F9 EC cells, combined with the observation that EC and ES cells utilize the proximal and distal enhancers in differential manner, indicate the complex pattern of Oct3/4 gene regulation, which could reflect a cell type‐ and lineage‐specific expression of the gene in vivo.
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Synergism with Germ Line Transcription Factor Oct-4: Viral Oncoproteins Share the Ability To Mimic a Stem Cell-Specific Activity
Alexander Brehm,Kazuyuki Ohbo,Werner Zwerschke,Valérie Botquin,Pidder Jansen-Dürr,Hans R. Schöler +5 more
TL;DR: The results suggest that different viruses have evolved oncoproteins that share the ability to target Oct-4 and to mimic a stem cell-specific activity.