K
Keith Hoots
Researcher at University of Texas Health Science Center at Houston
Publications - 35
Citations - 7403
Keith Hoots is an academic researcher from University of Texas Health Science Center at Houston. The author has contributed to research in topics: Recombinant factor VIIa & Human leukocyte antigen. The author has an hindex of 21, co-authored 35 publications receiving 7071 citations. Previous affiliations of Keith Hoots include Northwestern University & University of Texas at Austin.
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Journal ArticleDOI
Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response
Catherine S. Manno,Glenn F. Pierce,Valder R. Arruda,Bertil Glader,Margaret V. Ragni,Rasko Jj,Margareth C. Ozelo,Keith Hoots,Blatt P,Barbara A. Konkle,Michael D. Dake,Robin D. Kaye,Mahmood K. Razavi,A Zajko,James L. Zehnder,Pradip Rustagi,Hiroyuki Nakai,A Chew,Debra G.B. Leonard,Debra G.B. Leonard,J F Wright,Ruth Lessard,Jurg M. Sommer,Michael Tigges,Denise E. Sabatino,A Luk,Haiyan Jiang,Federico Mingozzi,Linda B. Couto,Hildegund C.J. Ertl,Katherine A. High,Katherine A. High,Mark A. Kay +32 more
TL;DR: In this article, a single portal vein infusion of a recombinant adeno-associated viral vector (rAAV) expressing canine Factor IX (F.IX) resulted in long-term expression of therapeutic levels of F.IX in dogs with severe hemophilia B.
Journal ArticleDOI
HLA and HIV-1: heterozygote advantage and B*35-Cw*04 disadvantage.
Mary Carrington,George W. Nelson,Maureen P. Martin,Teri Kissner,David Vlahov,James J. Goedert,Richard A. Kaslow,Susan Buchbinder,Keith Hoots,Stephen J. O'Brien +9 more
TL;DR: The extended survival of 28 to 40 percent of HIV-1-infected Caucasian patients who avoided AIDS for ten or more years can be attributed to their being fully heterozygous at HLA class I loci, to their lacking the AIDS-associated alleles B*35 and Cw*04, or to both.
Journal ArticleDOI
Epistatic interaction between KIR3DS1 and HLA-B delays the progression to AIDS
Maureen P. Martin,Xiaojiang Gao,Jeong Hee Lee,George W. Nelson,Roger Detels,James J. Goedert,Susan Buchbinder,Keith Hoots,David Vlahov,John Trowsdale,Michael A Wilson,Michael A Wilson,Stephen J. O'Brien,Mary Carrington +13 more
TL;DR: The strongest synergistic effect of these loci was on progression to depletion of CD4+ T cells, which suggests that a protective response of NK cells involving KIR3DS1 and its HLA class I ligands begins soon after HIV-1 infection.
Journal ArticleDOI
Contrasting Genetic Influence of CCR2 and CCR5 Variants on HIV-1 Infection and Disease Progression
Michael W. Smith,Michael Dean,Mary Carrington,Cheryl A. Winkler,Gavin A. Huttley,Deborah A. Lomb,James J. Goedert,Thomas R. O'Brien,Lisa P. Jacobson,Richard A. Kaslow,Susan Buchbinder,Eric Vittinghoff,David Vlahov,Keith Hoots,Margaret W. Hilgartner,Stephen J. O'Brien +15 more
TL;DR: Genetic association analysis of five acquired immunodeficiency syndrome (AIDS) cohorts revealed that although CCR2-64I exerts no influence on the incidence of HIV- 1 infection, HIV-1-infected individuals carrying the C CR2- 64I allele progressed to AIDS 2 to 4 years later than individuals homozygous for the common allele.
Journal ArticleDOI
Effect of a single amino acid change in MHC class I molecules on the rate of progression to AIDS.
Xiaojiang Gao,George W. Nelson,Peter Karacki,Maureen P. Martin,John P. Phair,Richard A. Kaslow,James J. Goedert,Susan Buchbinder,Keith Hoots,David Vlahov,Stephen J. O'Brien,Mary Carrington,Mary Carrington +12 more
TL;DR: This analysis shows that, in patients with HIV-1 infection, a single amino acid change in HLA molecules has a substantial effect on the rate of progression to AIDS.