K
Keli L. Hippen
Researcher at University of Minnesota
Publications - 72
Citations - 6492
Keli L. Hippen is an academic researcher from University of Minnesota. The author has contributed to research in topics: Regulatory T cell & Immune system. The author has an hindex of 33, co-authored 65 publications receiving 5660 citations. Previous affiliations of Keli L. Hippen include University of Colorado Hospital.
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Journal ArticleDOI
Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics.
Claudio G. Brunstein,Jeffrey S. Miller,Qing Cao,David H. McKenna,Keli L. Hippen,Julie M. Curtsinger,Todd E. DeFor,Bruce L. Levine,Carl H. June,Pablo Rubinstein,Philip B. McGlave,Bruce R. Blazar,John E. Wagner +12 more
TL;DR: There was a reduced incidence of grade II-IV aGVHD with no deleterious effect on risks of infection, relapse, or early mortality and the results set the stage for a definitive study of UCB Treg to determine its potency in preventing allogeneic aGV HD.
Journal ArticleDOI
Recruitment and activation of PTP1C in negative regulation of antigen receptor signaling by Fc gamma RIIB1.
Daniele D'Ambrosio,Keli L. Hippen,Stacey A. Minskoff,Ira Mellman,Giovanni Pani,Kathy Siminovitch,John C. Cambier +6 more
TL;DR: It was shown that the Fc gamma RIIB1 recruits the phosphotyrosine phosphatase PTP1C after BCR coligation, and this association is mediated by the binding of a 13-amino acid tyrosine-phosphorylated sequence to the carboxyl-terminal Src homology 2 domain of PTP 1C and activates P TP1C.
Journal ArticleDOI
Massive ex Vivo Expansion of Human Natural Regulatory T Cells (T regs ) with Minimal Loss of in Vivo Functional Activity
Keli L. Hippen,Sarah C. Merkel,Dawn K. Schirm,Christine M. Sieben,Darin Sumstad,Diane Kadidlo,David H. McKenna,Jonathan S. Bromberg,Bruce L. Levine,James L. Riley,Carl H. June,Phillip Scheinberg,Daniel C. Douek,Jeffrey S. Miller,John E. Wagner,Bruce R. Blazar +15 more
TL;DR: A new way to expand Tregs to numbers much larger than those previously achieved while maintaining their ability to selectively suppress self-attacking cytotoxic T cells in vivo is reported.
Journal ArticleDOI
Umbilical cord blood–derived T regulatory cells to prevent GVHD: kinetics, toxicity profile, and clinical effect
Claudio G. Brunstein,Jeffrey S. Miller,David H. McKenna,Keli L. Hippen,Todd E. DeFor,Darin Sumstad,Julie M. Curtsinger,Michael R. Verneris,Margaret L. MacMillan,Bruce L. Levine,James L. Riley,Carl H. June,Chap T. Le,Daniel J. Weisdorf,Philip B. McGlave,Bruce R. Blazar,John E. Wagner +16 more
TL;DR: Hematopoietic recovery and chimerism, cumulative density of infections, nonrelapse mortality, relapse, and disease-free survival were similar in the Treg recipients and controls.
Journal ArticleDOI
Clearance of Acute Myeloid Leukemia by Haploidentical Natural Killer Cells Is Improved Using IL-2 Diphtheria Toxin Fusion Protein
Veronika Bachanova,Sarah Cooley,Todd E. DeFor,Michael R. Verneris,Bin Zhang,David H. McKenna,Julie M. Curtsinger,Angela Panoskaltsis-Mortari,Dixie Lewis,Keli L. Hippen,Philip B. McGlave,Daniel J. Weisdorf,Bruce R. Blazar,Jeffrey S. Miller +13 more
TL;DR: The need to optimize the in vivo cytokine milieu where adoptively transferred NK cells compete with other lymphocytes to improve clinical efficacy in patients with refractory AML is supported.