K
Kelly M. Wetmore
Researcher at Lawrence Berkeley National Laboratory
Publications - 38
Citations - 2337
Kelly M. Wetmore is an academic researcher from Lawrence Berkeley National Laboratory. The author has contributed to research in topics: Gene & Mutant. The author has an hindex of 18, co-authored 34 publications receiving 1807 citations. Previous affiliations of Kelly M. Wetmore include University of California, Berkeley.
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Journal ArticleDOI
Mutant phenotypes for thousands of bacterial genes of unknown function
Morgan N. Price,Kelly M. Wetmore,Robert Jordan Waters,Mark Callaghan,Jayashree Ray,Hualan Liu,Jennifer V. Kuehl,Ryan A. Melnyk,Jacob S. Lamson,Yumi Suh,Hans K. Carlson,Zuelma Esquivel,Harini Sadeeshkumar,Romy Chakraborty,Grant M. Zane,Benjamin E. Rubin,Judy D. Wall,Axel Visel,Axel Visel,James Bristow,Matthew J. Blow,Adam P. Arkin,Adam P. Arkin,Adam M. Deutschbauer,Adam M. Deutschbauer +24 more
TL;DR: A large-scale mutagenesis screen identifies mutant phenotypes for over 11,000 protein-coding genes in bacteria that had previously not been assigned a specific function, demonstrating the scalability of microbial genetics and its utility for improving gene annotations.
Journal ArticleDOI
Rapid Quantification of Mutant Fitness in Diverse Bacteria by Sequencing Randomly Bar-Coded Transposons
Kelly M. Wetmore,Morgan N. Price,Robert Jordan Waters,Jacob S. Lamson,Jennifer He,Cindi A. Hoover,Matthew J. Blow,James Bristow,Gareth Butland,Adam P. Arkin,Adam P. Arkin,Adam M. Deutschbauer +11 more
TL;DR: An approach, random bar code transposon-site sequencing (RB-TnSeq), which greatly simplifies the measurement of gene fitness by using bar code sequencing (BarSeq) to monitor the abundance of mutants.
Journal ArticleDOI
The Epigenomic Landscape of Prokaryotes
Matthew J. Blow,Matthew J. Blow,Tyson A. Clark,Chris Daum,Chris Daum,Adam M. Deutschbauer,Alexey Fomenkov,Roxanne Fries,Roxanne Fries,Jeff Froula,Jeff Froula,Dongwan D. Kang,Dongwan D. Kang,Rex R. Malmstrom,Rex R. Malmstrom,Richard D. Morgan,Janos Posfai,Kanwar Singh,Kanwar Singh,Axel Visel,Axel Visel,Kelly M. Wetmore,Zhiying Zhao,Zhiying Zhao,Edward M. Rubin,Edward M. Rubin,Jonas Korlach,Len A. Pennacchio,Len A. Pennacchio,Richard J. Roberts +29 more
TL;DR: The results reveal the pervasive presence ofDNA methylation throughout the prokaryotic kingdoms, as well as the diversity of sequence specificities and potential functions of DNA methylation systems.
Journal ArticleDOI
The essential gene set of a photosynthetic organism.
Benjamin E. Rubin,Kelly M. Wetmore,Morgan N. Price,Spencer Diamond,Ryan K. Shultzaberger,Laura C. Lowe,Genevieve Curtin,Adam P. Arkin,Adam P. Arkin,Adam M. Deutschbauer,Susan S. Golden +10 more
TL;DR: Experimental analysis of the complete set of genomic regions necessary for survival in a cyanobacterium achieved by screening for the fitness of hundreds of thousands of mutants provides a snapshot of the essential genes and intergenic regions necessary to live the photosynthetic lifestyle.
Journal ArticleDOI
Genome-wide identification of bacterial plant colonization genes.
Benjamin J. Cole,Meghan E. Feltcher,Robert Jordan Waters,Kelly M. Wetmore,Tatiana S. Mucyn,Elizabeth M. Ryan,Gaoyan Wang,Sabah Ul-Hasan,Sabah Ul-Hasan,Meredith McDonald,Yasuo Yoshikuni,Yasuo Yoshikuni,Rex R. Malmstrom,Adam M. Deutschbauer,Jeffery L. Dangl,Axel Visel,Axel Visel,Axel Visel +17 more
TL;DR: Analysis of bacterial genes by sequence-driven saturation mutagenesis revealed a genome-wide map of the genetic determinants of plant root colonization and offers a starting point for targeted improvement of the colonization capabilities of plant-beneficial microbes.