M
Meghan E. Feltcher
Researcher at University of North Carolina at Chapel Hill
Publications - 13
Citations - 1605
Meghan E. Feltcher is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Mycobacterium tuberculosis & Twin-arginine translocation pathway. The author has an hindex of 11, co-authored 13 publications receiving 1136 citations. Previous affiliations of Meghan E. Feltcher include Research Triangle Park & Howard Hughes Medical Institute.
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Journal ArticleDOI
Root microbiota drive direct integration of phosphate stress and immunity
Gabriel Castrillo,Paulo José Pereira Lima Teixeira,Sur Herrera Paredes,Theresa F. Law,Laura de Lorenzo,Meghan E. Feltcher,Omri M. Finkel,Natalie W. Breakfield,Natalie W. Breakfield,Piotr A. Mieczkowski,Corbin D. Jones,Javier Paz-Ares,Jeffery L. Dangl +12 more
TL;DR: It is established that a genetic network controlling the phosphate stress response influences the structure of the root microbiome community, even under non-stress phosphate conditions, and that the master transcriptional regulators of phosphate Stress Response in Arabidopsis thaliana directly repress defence, consistent with plant prioritization of nutritional stress over defence.
Journal ArticleDOI
Genomic features of bacterial adaptation to plants.
Asaf Levy,Isai Salas González,Isai Salas González,Maximilian Mittelviefhaus,Scott Clingenpeel,Sur Herrera Paredes,Sur Herrera Paredes,Sur Herrera Paredes,Jiamin Miao,Jiamin Miao,Kunru Wang,Giulia Devescovi,Kyra Stillman,Freddy Monteiro,Freddy Monteiro,Bryan Rangel Alvarez,Derek S. Lundberg,Derek S. Lundberg,Tse-Yuan Lu,Sarah L. Lebeis,Zhao Jin,Meredith McDonald,Meredith McDonald,Andrew P. Klein,Andrew P. Klein,Meghan E. Feltcher,Meghan E. Feltcher,Meghan E. Feltcher,Tijana Glavina del Rio,Sarah R. Grant,Sharon L. Doty,Ruth E. Ley,Bingyu Zhao,Vittorio Venturi,Dale A. Pelletier,Julia A. Vorholt,Susannah G. Tringe,Susannah G. Tringe,Tanja Woyke,Tanja Woyke,Jeffery L. Dangl +40 more
TL;DR: This work sequenced 484 genomes of bacterial isolates from roots of Brassicaceae, poplar, and maize and validated candidates from two sets of plant-associated genes, including one involved in plant colonization and the other serving in microbe–microbe competition between plant and microbe.
Journal ArticleDOI
Design of synthetic bacterial communities for predictable plant phenotypes.
Sur Herrera Paredes,Tianxiang Gao,Theresa F. Law,Omri M. Finkel,Tatiana S. Mucyn,Paulo José Pereira Lima Teixeira,Isai Salas González,Meghan E. Feltcher,Matthew J. Powers,Elizabeth A. Shank,Corbin D. Jones,Vladimir Jojic,Jeffery L. Dangl,Gabriel Castrillo +13 more
TL;DR: It is demonstrated that plant–bacterium binary-association assays inform the design of small synthetic communities with predictable phenotypes in the host and that it is possible to infer causal relationships between microbiota membership and host phenotypes and to use these inferences to rationally design novel communities.
Journal ArticleDOI
Genome-wide identification of bacterial plant colonization genes.
Benjamin J. Cole,Meghan E. Feltcher,Robert Jordan Waters,Kelly M. Wetmore,Tatiana S. Mucyn,Elizabeth M. Ryan,Gaoyan Wang,Sabah Ul-Hasan,Sabah Ul-Hasan,Meredith McDonald,Yasuo Yoshikuni,Yasuo Yoshikuni,Rex R. Malmstrom,Adam M. Deutschbauer,Jeffery L. Dangl,Axel Visel,Axel Visel,Axel Visel +17 more
TL;DR: Analysis of bacterial genes by sequence-driven saturation mutagenesis revealed a genome-wide map of the genetic determinants of plant root colonization and offers a starting point for targeted improvement of the colonization capabilities of plant-beneficial microbes.
Journal ArticleDOI
Protein export systems of Mycobacterium tuberculosis: novel targets for drug development?
TL;DR: The current understanding of the protein export systems of M. tuberculosis is discussed and the potential of these pathways to be novel targets for tuberculosis drugs is considered.