Richard D. Morgan

TL;DR: In this article, a nomenclature for restriction endonucleases, DNA methyltransferases, homing endon nucleases and related genes and gene products is described.

TL;DR: The results reveal the pervasive presence ofDNA methylation throughout the prokaryotic kingdoms, as well as the diversity of sequence specificities and potential functions of DNA methylation systems.

TL;DR: SMRT sequencing confirms the identity and position of the methylated base in cases where the MTase specificity was previously established by other methods and finds evidence of unanticipated MTase promiscuity with some enzymes apparently also modifying sequences that are related, but not identical to the cognate site.

TL;DR: This study shows that the addition of SMRT sequencing to traditional sequencing approaches gives a wealth of useful functional information about a genome showing not only which MTase genes are active but also revealing their recognition sequences.

TL;DR: This community page discusses the progress made by the COMBREX project to address this important issue using both computational and experimental resources.