K
Kemly Philip
Researcher at University of Texas Health Science Center at Houston
Publications - 13
Citations - 594
Kemly Philip is an academic researcher from University of Texas Health Science Center at Houston. The author has contributed to research in topics: Fibrosis & Idiopathic pulmonary fibrosis. The author has an hindex of 9, co-authored 13 publications receiving 426 citations. Previous affiliations of Kemly Philip include Memorial Hermann Healthcare System & University of Texas at Austin.
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Journal ArticleDOI
Blockade of IL-6 Trans Signaling Attenuates Pulmonary Fibrosis
Thanh-Thuy T. Le,Harry Karmouty-Quintana,Ernestina Melicoff,Thanh-Truc T. Le,Tingting Weng,Ning Yuan Chen,Mesias Pedroza,Yang Zhou,Jonathan Davies,Kemly Philip,Jose G. Molina,Fayong Luo,Anuh T. George,Luis J. Garcia-Morales,R.R. Bunge,Brian A. Bruckner,Matthias Loebe,Harish Seethamraju,Sandeep K. Agarwal,Michael R. Blackburn,Michael R. Blackburn +20 more
TL;DR: It is demonstrated that the production of sIL-6Rα from macrophages in the diseased lung contributes to IL-6 trans signaling that in turn influences events crucial in pulmonary fibrosis.
Journal ArticleDOI
Deletion of ADORA2B from myeloid cells dampens lung fibrosis and pulmonary hypertension
Harry Karmouty-Quintana,Kemly Philip,Luis F. Acero,Ning Yuan Chen,Tingting Weng,Jose G. Molina,Fayong Luo,Jonathan Davies,Ngoc Bao Le,Isabelle Bunge,Kelly A. Volcik,Thanh-Thuy T. Le,Richard A. Johnston,Yang Xia,Holger K. Eltzschig,Michael R. Blackburn +15 more
TL;DR: Activation of the ADORA2B on macrophages plays an active role in the pathogenesis of lung fibrosis and PH and is associated with reduced expression of CD206 and arginase‐1, markers for AAMs.
Journal ArticleDOI
Macrophage bone morphogenic protein receptor 2 depletion in idiopathic pulmonary fibrosis and Group III pulmonary hypertension
Ning Yuan Chen,Scott D. Collum,Fayong Luo,Tingting Weng,Thuy T. Le,Adriana M. Hernandez,Kemly Philip,Jose G. Molina,Luis J. Garcia-Morales,Yanna Cao,Tien C. Ko,Javier Amione-Guerra,Odeaa Al-Jabbari,R.R. Bunge,Keith A. Youker,Brian A. Bruckner,Rizwan Hamid,Jonathan Davies,Neeraj Sinha,Harry Karmouty-Quintana +19 more
TL;DR: The data suggest that depletion of BMPR2 mediated by a collection of miRs induced by IL6 and subsequent STAT3 phosphorylation as a novel mechanism participating to fibroproliferative and vascular injuries in IPF.
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HIF1A up-regulates the ADORA2B receptor on alternatively activated macrophages and contributes to pulmonary fibrosis
Kemly Philip,Tingting Mills,Jonathan Davies,Ning Yuan Chen,Harry Karmouty-Quintana,Fayong Luo,Jose G. Molina,Javier Amione-Guerra,Neeraj Sinha,Ashrith Guha,Holger K. Eltzschig,Michael R. Blackburn +11 more
TL;DR: It is demonstrated that hypoxia‐inducible factor 1‐α (HIF1A) inhibition in late stages of bleomycin‐induced injury attenuates pulmonary fibrosis in association, with reductions in ADORA2B expression in AAMs.
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Cleavage factor 25 deregulation contributes to pulmonary fibrosis through alternative polyadenylation
Tingting Weng,Junsuk Ko,Chioniso P. Masamha,Zheng Xia,Yu Xiang,Ning Yuan Chen,Jose G. Molina,Scott D. Collum,Tinne C.J. Mertens,Fayong Luo,Kemly Philip,Jonathan Davies,Jingjing Huang,Cory Wilson,Rajarajan Amirthalingam Thandavarayan,Brian A. Bruckner,S. Jyothula,Kelly A. Volcik,Lei Li,Leng Han,Wei Li,Shervin Assassi,Harry Karmouty-Quintana,Eric J. Wagner,Michael R. Blackburn +24 more
TL;DR: It is demonstrated that CFIm25, a global regulator of APA, is down-regulated in the lungs of patients with IPF and mice with pulmonary fibrosis, with its expression selectively reduced in alpha-smooth muscle actin positive fibroblasts.