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Harry Karmouty-Quintana
Researcher at University of Texas Health Science Center at Houston
Publications - 108
Citations - 3623
Harry Karmouty-Quintana is an academic researcher from University of Texas Health Science Center at Houston. The author has contributed to research in topics: Lung & Fibrosis. The author has an hindex of 31, co-authored 79 publications receiving 2729 citations. Previous affiliations of Harry Karmouty-Quintana include McGill University & King's College London.
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Journal ArticleDOI
Muc5b is required for airway defence
Michelle G. Roy,Alessandra Livraghi-Butrico,Ashley A. Fletcher,Melissa M. McElwee,Scott E. Evans,Ryan M. Boerner,Samantha N. Alexander,Lindsey K. Bellinghausen,Alfred S. Song,Youlia Petrova,Michael J. Tuvim,Roberto Adachi,Irlanda Romo,Andrea S. Bordt,M. Gabriela Bowden,M. Gabriela Bowden,Joseph H. Sisson,Prescott G. Woodruff,David J. Thornton,Karine Rousseau,Maria Miguelina De La Garza,Seyed Javad Moghaddam,Harry Karmouty-Quintana,Michael R. Blackburn,Scott M. Drouin,C. William Davis,Kristy A. Terrell,Barbara R. Grubb,Wanda K. O'Neal,Sonia C. Flores,Adela Cota-Gomez,Catherine A. Lozupone,Jody Donnelly,Alan M. Watson,Corinne E. Hennessy,Rebecca C. Keith,Ivana V. Yang,Lea Barthel,Peter M. Henson,William J. Janssen,David A. Schwartz,Richard C. Boucher,Burton F. Dickey,Christopher M. Evans,Christopher M. Evans +44 more
TL;DR: It is shown that mouse Muc5b (but not MUC5ac) is required for MCC, for controlling infections in the airways and middle ear, and for maintaining immune homeostasis in mouse lungs, whereas Muc 5ac is dispensable.
Journal ArticleDOI
Blockade of IL-6 Trans Signaling Attenuates Pulmonary Fibrosis
Thanh-Thuy T. Le,Harry Karmouty-Quintana,Ernestina Melicoff,Thanh-Truc T. Le,Tingting Weng,Ning Yuan Chen,Mesias Pedroza,Yang Zhou,Jonathan Davies,Kemly Philip,Jose G. Molina,Fayong Luo,Anuh T. George,Luis J. Garcia-Morales,R.R. Bunge,Brian A. Bruckner,Matthias Loebe,Harish Seethamraju,Sandeep K. Agarwal,Michael R. Blackburn,Michael R. Blackburn +20 more
TL;DR: It is demonstrated that the production of sIL-6Rα from macrophages in the diseased lung contributes to IL-6 trans signaling that in turn influences events crucial in pulmonary fibrosis.
Journal ArticleDOI
STAT-3 contributes to pulmonary fibrosis through epithelial injury and fibroblast-myofibroblast differentiation
Mesias Pedroza,Thuy T. Le,Katherine Lewis,Harry Karmouty-Quintana,Sarah To,Anuh T. George,Michael R. Blackburn,David J. Tweardy,Sandeep K. Agarwal +8 more
TL;DR: It is demonstrated that STAT‐3 contributes to the development of lung fibrosis and suggest thatSTAT‐3 may be a therapeutic target in pulmonary fibrosis.
Journal ArticleDOI
Adenosine signaling during acute and chronic disease states
TL;DR: Key observations are discussed that define the beneficial and detrimental aspects of adenosine signaling during acute and chronic disease states with an emphasis on cellular processes, such as inflammatory cell regulation, vascular barrier function, and tissue fibrosis.
Journal ArticleDOI
Beneficial Role of Erythrocyte Adenosine A2B Receptor–Mediated AMP-Activated Protein Kinase Activation in High-Altitude Hypoxia
Hong Liu,Yujin Zhang,Hongyu Wu,Angelo D'Alessandro,Gennady G. Yegutkin,Anren Song,Kaiqi Sun,Jessica Li,Ning-Yuan Cheng,Aji Huang,Yuan Edward Wen,Ting Ting Weng,Fayong Luo,Travis Nemkov,Hong Sun,Rodney E. Kellems,Harry Karmouty-Quintana,Kirk C. Hansen,Bihong Zhao,Andrew W. Subudhi,Sonja Jameson-Van Houten,Colleen G. Julian,Andrew T. Lovering,Holger K. Eltzschig,Michael R. Blackburn,Robert C. Roach,Yang Xia +26 more
TL;DR: Together, human and mouse studies reveal novel mechanisms of hypoxia adaptation and potential therapeutic approaches for counteracting Hypoxia-induced tissue damage.