L
Lei Li
Researcher at University of Texas MD Anderson Cancer Center
Publications - 128
Citations - 8568
Lei Li is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: DNA repair & DNA damage. The author has an hindex of 51, co-authored 99 publications receiving 7592 citations. Previous affiliations of Lei Li include Life Sciences Institute & Max Planck Society.
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Journal ArticleDOI
Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas
Theo A. Knijnenburg,Linghua Wang,Michael T. Zimmermann,Nyasha Chambwe,Galen F. Gao,Andrew D. Cherniack,Huihui Fan,Hui Shen,Gregory P. Way,Casey S. Greene,Yuexin Liu,Rehan Akbani,Bin Feng,Lawrence A. Donehower,Chase Miller,Yang Shen,Mostafa Karimi,Haoran Chen,Pora Kim,Peilin Jia,Eve Shinbrot,Shaojun Zhang,Jianfang Liu,Hai Hu,Matthew H. Bailey,Christina Yau,Denise M. Wolf,Zhongming Zhao,John N. Weinstein,Lei Li,Li Ding,Gordon B. Mills,Peter W. Laird,David A. Wheeler,Ilya Shmulevich,Raymond J. Monnat,Yonghong Xiao,Chen Wang +37 more
TL;DR: These frequent DDR gene alterations in many human cancers have functional consequences that may determine cancer progression and guide therapy and a new machine-learning-based classifier developed from gene expression data allowed to identify alterations that phenocopy deleterious TP53 mutations.
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The Cockayne syndrome group A gene encodes a WD repeat protein that interacts with CSB protein and a subunit of RNA polymerase II TFIIH
Karla A. Henning,Lei Li,Narayan V. Iyer,Lisa D. McDaniel,Michael S. Reagan,Randy J. Legerski,Roger A. Schultz,Miria Stefanini,Alan R. Lehmann,Lynne V. Mayne,Errol C. Friedberg +10 more
TL;DR: The cloned CSB gene encodes a member of a protein family that includes the yeast Snf2 protein, a component of the transcriptional regulator Swi/Snf, which can encode a WD repeat protein.
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Polymorphisms of DNA repair gene XRCC1 in squamous cell carcinoma of the head and neck.
Erich M. Sturgis,Edward J. Castillo,Lei Li,Rong Zheng,Susan A. Eicher,Gary L. Clayman,Sara S. Strom,Margaret R. Spitz,Qingyi Wei +8 more
TL;DR: The hypothesis that a polymorphic XRCC1 DNA repair gene contributes to risk of developing SCCHN is supported.
Journal Article
Combination of EGFR, HER-2/neu, and HER-3 Is a Stronger Predictor for the Outcome of Oral Squamous Cell Carcinoma Than Any Individual Family Members
Weiya Xia,Yiu Keung Lau,Hua Zhong Zhang,Fen Yuan Xiao,Dennis A. Johnston,Ai Ru Liu,Lei Li,Ruth L. Katz,Mien Chie Hung +8 more
TL;DR: Exercise of the expression levels of EGFR, HER-2/ neu, and HER-3 may help predict the outcome of patients with oral SCC, and the combination of Her-2, Her-3, and EGFR but not HER-4 significantly improved the predicting power.
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Specific association between the human DNA repair proteins XPA and ERCC1
TL;DR: It is suggested that XPA may play a role in the localization or loading of an incision complex, composed of ERCC1 and possibly other repair factors, onto a damaged site.