Hiromi Miki

TL;DR: In vitro culture of spermatogonial stem cells that proliferate for long periods of time are reported, and gonocytes isolated from neonatal mouse testis proliferated over a 5-month period and restored fertility to congenitally infertile recipient mice following transplantation into seminiferous tubules.

TL;DR: The successful establishment of ES-like cells from neonatal mouse testis were phenotypically similar to ES/EG cells except in their genomic imprinting pattern and differentiated into various types of somatic cells in vitro under conditions used to induce the differentiation of ES cells.

TL;DR: The production of mice that lack Peg10 indicates that Peg10 is critical for mouse parthenogenetic development and provides the first direct evidence of an essential role of an evolutionarily conserved retrotransposon-derived gene in mammalian development.

TL;DR: This investigation examined the possibility of establishing culture systems for spermatogonial stem cells that lack serum or a feeder cell layer and found that cells cultured on laminin grew exponentially for at least 6 mo, and produced normal, fertile progeny following transplantation into infertile mouse testis.

TL;DR: This approach of 'testicular tissue banking' is a promising technique for the preservation of fertility in prepubertal male oncology patients and Xenogeneic transplantation into immunodeficient mice may provide a system for studying spermatogenic failure in infertile men.