Ken Takai

TL;DR: Understanding the mechanisms of ECM remodeling and its regulation is essential for developing new therapeutic interventions for diseases and novel strategies for tissue engineering and regenerative medicine.

TL;DR: It is shown at the single-cell level that early stage metastatic cells possess a distinct stem-like gene expression signature, which supports a hierarchical model for metastasis, in which metastases are initiated by stem- like cells that proliferate and differentiate to produce advanced metastatic disease.

TL;DR: It is shown that transgenic expression of HBZ in CD4+ T cells induced T-cell lymphomas and systemic inflammation in mice, resembling diseases observed in HTLV-1 infected individuals.

TL;DR: PFD has great potential for a novel clinically applicable TNBC therapy that targets tumor-stromal interaction and inhibited tumor growth and lung metastasis synergistically in combination with doxorubicin.

TL;DR: A molecular phylogenetic survey of naturally occurring archaeal diversities in hot water environments was carried out by using the PCR-mediated small subunit rRNA gene (SSU rDNA) sequencing, which revealed the distant relationship not only to the rDNA sequences of the cultivated thermophilic archaea, but also to the sequences of unidentifiedarchaeal rDNA clones found in other hotWater environments.