K
Karin D. Prummel
Researcher at University of Zurich
Publications - 13
Citations - 980
Karin D. Prummel is an academic researcher from University of Zurich. The author has contributed to research in topics: Lateral plate mesoderm & Zebrafish. The author has an hindex of 6, co-authored 10 publications receiving 737 citations. Previous affiliations of Karin D. Prummel include University of California, San Francisco & University of Colorado Denver.
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Journal ArticleDOI
Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cells.
Devon A. Lawson,Nirav R. Bhakta,Kai Kessenbrock,Kai Kessenbrock,Karin D. Prummel,Ying Yu,Ken Takai,Alicia Y. Zhou,Henok Eyob,Sanjeev Balakrishnan,Chih Yang Wang,Chih Yang Wang,Paul Yaswen,Andrei Goga,Zena Werb +14 more
TL;DR: It is shown at the single-cell level that early stage metastatic cells possess a distinct stem-like gene expression signature, which supports a hierarchical model for metastasis, in which metastases are initiated by stem- like cells that proliferate and differentiate to produce advanced metastatic disease.
Journal ArticleDOI
The lateral plate mesoderm
Karin D. Prummel,Karin D. Prummel,Susan Nieuwenhuize,Susan Nieuwenhuize,Christian Mosimann,Christian Mosimann +5 more
TL;DR: The lateral plate mesoderm is the origin of several major cell types and organ systems in the vertebrate body plan and how this Mesoderm territory emerges and partitions into its downstream fates provides clues about vertebrate development and evolution.
Journal ArticleDOI
Mutations in Bcl9 and Pygo genes cause congenital heart defects by tissue-specific perturbation of Wnt/β-catenin signaling.
Claudio Cantù,Anastasia Felker,Dario Zimmerli,Karin D. Prummel,Elena Maria Cabello,Elena Chiavacci,Kevin M. Méndez-Acevedo,Lucia Kirchgeorg,Sibylle Burger,Jorge Ripoll,Tomas Valenta,George Hausmann,Nathalie Vilain,Michel Aguet,Alexa Burger,Daniela Panáková,Konrad Basler,Christian Mosimann +17 more
TL;DR: Combining zebrafish and mouse genetics, this work document a conserved, β-catenin-associated function for BCL9 and Pygo proteins during vertebrate heart development and implicate alterations in B CL9 and BCL 9L in human congenital heart defects.
Journal ArticleDOI
Continuous addition of progenitors forms the cardiac ventricle in zebrafish.
Anastasia Felker,Karin D. Prummel,Anne M. Merks,Michaela Mickoleit,Eline C. Brombacher,Jan Huisken,Jan Huisken,Daniela Panáková,Christian Mosimann +8 more
TL;DR: High-speed imaging and optogenetic lineage tracing corroborates that the zebrafish ventricle forms through continuous addition from the undifferentiated progenitor sheath followed by late-phase accrual of the bulbus arteriosus (BA).
Journal ArticleDOI
A conserved regulatory program initiates lateral plate mesoderm emergence across chordates.
Karin D. Prummel,Christopher P. Hess,Susan Nieuwenhuize,Hugo J. Parker,Hugo J. Parker,Katherine W Rogers,Iryna Kozmikova,Claudia Racioppi,Eline C. Brombacher,Anna Czarkwiani,Dunja Knapp,Sibylle Burger,Elena Chiavacci,Gopi Shah,Alexa Burger,Jan Huisken,Jan Huisken,Maximina H. Yun,Lionel Christiaen,Zbynek Kozmik,Patrick Müller,Marianne E. Bronner,Robb Krumlauf,Robb Krumlauf,Christian Mosimann +24 more
TL;DR: This work identifies a pan-LPM reporter activity found in the zebrafish draculin (drl) gene that also shows transgenic activity in LPM-corresponding territories of several chordates, including chicken, axolotl, lamprey, Ciona, and amphioxus, revealing a universal upstream LPM program.