T
Tiejun Zhao
Researcher at Zhejiang Normal University
Publications - 32
Citations - 1758
Tiejun Zhao is an academic researcher from Zhejiang Normal University. The author has contributed to research in topics: Gene & T-cell leukemia. The author has an hindex of 15, co-authored 26 publications receiving 1440 citations. Previous affiliations of Tiejun Zhao include Kyoto University & Nankai University.
Papers
More filters
Journal ArticleDOI
Suppression of tumorigenesis by human mesenchymal stem cells in a hepatoma model.
Ling Qiao,Zhili Xu,Tiejun Zhao,Zhigang Zhao,Mingxia Shi,Robert Chunhua Zhao,Lihong Ye,Xiaodong Zhang +7 more
TL;DR: It is demonstrated that hMSCs inhibit the malignant phenotypes of the H7402 and HepG2 human liver cancer cell lines, which include proliferation, colony-forming ability and oncogene expression both in vitro and in vivo.
Journal ArticleDOI
Dkk-1 secreted by mesenchymal stem cells inhibits growth of breast cancer cells via depression of Wnt signalling.
TL;DR: The finding showed that beta-catenin was down-regulated in MCF-7 cells by conditioned media from Z3 hMSCs, and the expression level of dickkopf-1 (Dkk-1) was higher in Z3 cells than that inMCF- 7 cells, suggesting that DKK-1 secreted by Z3 Cells involves the inhibition via the Wnt pathway.
Journal ArticleDOI
HTLV-1 bZIP factor induces T-cell lymphoma and systemic inflammation in vivo.
Yorifumi Satou,Jun-ichirou Yasunaga,Tiejun Zhao,Mika Yoshida,Paola Miyazato,Ken Takai,Kei Shimizu,Koichi Ohshima,Patrick L. Green,Naganari Ohkura,Tomoyuki Yamaguchi,Masahiro Ono,Shimon Sakaguchi,Masao Matsuoka +13 more
TL;DR: It is shown that transgenic expression of HBZ in CD4+ T cells induced T-cell lymphomas and systemic inflammation in mice, resembling diseases observed in HTLV-1 infected individuals.
Journal ArticleDOI
Human T-cell leukemia virus type 1 bZIP factor selectively suppresses the classical pathway of NF-κB
Tiejun Zhao,Jun-ichirou Yasunaga,Yorifumi Satou,Mitsuyoshi Nakao,Masahiko Takahashi,Masahiro Fujii,Masao Matsuoka +6 more
TL;DR: HBZ specifically suppressed NF-kappaB-driven transcription mediated by p65 (the classical pathway) without inhibiting the alternative NF- kappaB signaling pathway, which might be critical for oncogenesis.
Journal ArticleDOI
HTLV-1 bZIP factor enhances TGF-β signaling through p300 coactivator
Tiejun Zhao,Yorifumi Satou,Kenji Sugata,Paola Miyazato,Patrick L. Green,Takeshi Imamura,Takeshi Imamura,Masao Matsuoka +7 more
TL;DR: It is suggested that HBZ, by enhancing TGF-β signaling and Foxp3 expression, enables HTLV-1 to convert infected T cells into regulatory T cells, which is thought to be a critical strategy for virus persistence.