Kenichi Kobayashi

TL;DR: In this paper, the authors reviewed the standard results from each treatment based on an extensive survey and found that percutaneous ethanol injection (PEI), hepatic resection (HX), and transcatheter arterial embolization (TCAE) have all been used in the treatment of patients with small-sized hepatocellular carcinomas (HCCs).

TL;DR: Evaluation of the blood supply of the nodular lesions associated with liver cirrhosis is considered to be useful in the differential diagnosis and treatment of early-stage HCC.

TL;DR: Analysis by the PCR technique provides a greater than 10(4)-fold increase in sensitivity over the slot-blot hybridization assay, which represents an important breakthrough in sensitivity because it is now possible to detect as few as three HBV DNA genomes per sample of serum.

TL;DR: The C-terminal region of NS5B, which is dispensable for the RdRP activity, dramatically affected the subcellular localization ofNS5B retaining it in perinuclear sites in transiently overexpressed mammalian cells and may provide some clues to dissecting the molecular mechanism of the HCV replication and also act as a basis for developing new anti-viral drugs.

TL;DR: The idea that NS5A modulates HCV replication as a component of replication complex as well as the effect of His-NS5A on RdRP activity of the soluble recombinant NS5Bt in vitro is supported.