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Weiping Qin
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 55
Citations - 4451
Weiping Qin is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Muscle atrophy & Spinal cord injury. The author has an hindex of 28, co-authored 54 publications receiving 4076 citations. Previous affiliations of Weiping Qin include United States Department of Veterans Affairs & Veterans Health Administration.
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Journal ArticleDOI
Diet-induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer’s disease
Lap Ho,Weiping Qin,Patrick Pompl,Zhongmin Xiang,Jun Wang,Zhong Zhao,Yuanzhen Peng,Gina Cambareri,Anne B. Rocher,Charles V. Mobbs,Patrick R. Hof,Giulio Maria Pasinetti +11 more
TL;DR: It is found that diet‐induced insulin resistance promoted amyloidogenic β‐amyloid (Aβ) A β1–40 and Aβ1–42 peptide generation in the brain that corresponded with increased γ‐secretase activities and decreased insulin degrading enzyme (IDE) activities.
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Neuronal SIRT1 Activation as a Novel Mechanism Underlying the Prevention of Alzheimer Disease Amyloid Neuropathology by Calorie Restriction
Weiping Qin,Tianle Yang,Lap Ho,Lap Ho,Zhong Zhao,Jun Wang,Linghong Chen,Wei Zhao,Meenakshisundaram Thiyagarajan,Donal MacGrogan,Joseph T. Rodgers,Pere Puigserver,Junichi Sadoshima,Haiteng Deng,Steven Pedrini,Sam Gandy,Anthony A. Sauve,Giulio Maria Pasinetti,Giulio Maria Pasinetti +18 more
TL;DR: The predicted attenuation ofβ-amyloid content in the brain during CR can be reproduced in mouse neurons in vitro by manipulating cellular SIRT1 expression/activity through mechanisms involving the regulation of the serine/threonine Rho kinase ROCK1.
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PGC-1α Expression Decreases in the Alzheimer Disease Brain as a Function of Dementia
Weiping Qin,Vahram Haroutunian,Pavel Katsel,Christopher Cardozo,Lap Ho,Joseph D. Buxbaum,Giulio Maria Pasinetti +6 more
TL;DR: Therapeutic preservation of neuronal PGC-1alpha expression promotes the nonamyloidogenic processing of amyloid precursor protein precluding the generation of ameloidogenic Abeta peptides.
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Caloric restriction attenuates β-amyloid neuropathology in a mouse model of Alzheimer’s disease
Jun Wang,Lap Ho,Weiping Qin,Anne B. Rocher,Ilana Seror,Nelson Humala,Kruti P. Maniar,Georgia Dolios,Rong Wang,Patrick R. Hof,Giulio Maria Pasinetti +10 more
TL;DR: It is reported that a CR dietary regimen prevents Aβ peptides generation and neuritic plaque deposition in the brain of a mouse model of AD neuropathology through mechanisms associated with promotion of anti‐amyloidogenic α‐secretase activity.
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RNA-dependent RNA polymerase activity of the soluble recombinant hepatitis C virus NS5B protein truncated at the C-terminal region.
Tatsuya Yamashita,Shuichi Kaneko,Yukihiro Shirota,Weiping Qin,Takahiro Nomura,Kenichi Kobayashi,Seishi Murakami +6 more
TL;DR: The C-terminal region of NS5B, which is dispensable for the RdRP activity, dramatically affected the subcellular localization ofNS5B retaining it in perinuclear sites in transiently overexpressed mammalian cells and may provide some clues to dissecting the molecular mechanism of the HCV replication and also act as a basis for developing new anti-viral drugs.