K
Kenji Sasahara
Researcher at Osaka University
Publications - 22
Citations - 647
Kenji Sasahara is an academic researcher from Osaka University. The author has contributed to research in topics: Amyloid & Amyloidosis. The author has an hindex of 13, co-authored 22 publications receiving 564 citations. Previous affiliations of Kenji Sasahara include Kobe University.
Papers
More filters
Journal ArticleDOI
Heat-induced Conversion of β2-Microglobulin and Hen Egg-white Lysozyme into Amyloid Fibrils
TL;DR: The combined use of agitation and heating is a powerful way to generate amyloid fibrils from two proteins, β2-microglobulin and hen egg-white lysozyme, and to evaluate the effects of heat on fibrillation, in which the heat capacity is crucial to characterizing the transition.
Journal ArticleDOI
Effects of membrane interaction and aggregation of amyloid β-peptide on lipid mobility and membrane domain structure
TL;DR: It is proposed that Aβ aggregates formed in the presence of lipid membranes have a latent ability to trigger the uptake of raft components accompanied by phase separation of lipids.
Journal ArticleDOI
Amyloid Nucleation Triggered by Agitation of β2-Microglobulin under Acidic and Neutral pH Conditions
TL;DR: The agitation-treated aggregates of both proteins have a high propensity to produce an amyloid nucleus even at neutral pH, providing evidence that the aggregation pathway involves amyloids nucleation under entirely native conditions.
Journal ArticleDOI
A Comprehensive Model for Packing and Hydration for Amyloid Fibrils of β2-Microglobulin
TL;DR: The data imply that the mature amyloid fibrils are more voluminous than the native structure because of a sparse packing density of side chains, which would result from the nature of main-chain-dominated fibrillogenesis.
Journal ArticleDOI
Kinetically Controlled Thermal Response of β2-Microglobulin Amyloid Fibrils
TL;DR: It is suggested that the heating rate-dependent negative change in heat capacity is coupled to the association of amyloid fibrils with characteristic hydration pattern.