K
Kenneth Chan
Researcher at University of Washington
Publications - 46
Citations - 2816
Kenneth Chan is an academic researcher from University of Washington. The author has contributed to research in topics: Hopf algebra & Noncommutative geometry. The author has an hindex of 20, co-authored 46 publications receiving 2644 citations.
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Journal ArticleDOI
MicroRNA-29b induces global DNA hypomethylation and tumor suppressor gene reexpression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1.
Ramiro Garzon,Shujun Liu,Muller Fabbri,Zhongfa Liu,Catherine E. A. Heaphy,Elisa Callegari,Sebastian Schwind,Jiuxia Pang,Jianhua Yu,Natarajan Muthusamy,Violaine Havelange,Stefano Volinia,William Blum,Laura J. Rush,Danilo Perrotti,Michael Andreeff,Clara D. Bloomfield,John C. Byrd,Kenneth Chan,Lai-Chu Wu,Carlo M. Croce,Guido Marcucci +21 more
TL;DR: Novel functional links between miRNAs and aberrant DNA hypermethylation in acute myeloid leukemia and suggest a potentially therapeutic use of synthetic miR-29b oligonucleotides as effective hypomethylating compounds are provided.
Journal ArticleDOI
A phase 1 and pharmacodynamic study of depsipeptide (FK228) in chronic lymphocytic leukemia and acute myeloid leukemia
John C. Byrd,Guido Marcucci,Mark R. Parthun,Jim J. Xiao,Rebecca B. Klisovic,Mollie E. Moran,Thomas S. Lin,Shujun Liu,Amy R. Sklenar,Melanie E. Davis,David M. Lucas,Beth Fischer,Roshini S. Shank,Sooraj Tejaswi,Philip F. Binkley,John J. Wright,Kenneth Chan,Michael R. Grever +17 more
TL;DR: It is concluded that depsipeptide effectively inhibits HDAC in vivo in patients with CLL and AML, but its use in the current schedule of administration is limited by progressive constitutional symptoms.
Journal ArticleDOI
Cardiotoxicity of histone deacetylase inhibitor depsipeptide in patients with metastatic neuroendocrine tumors.
Manisha H. Shah,Philip F. Binkley,Kenneth Chan,Jim J. Xiao,Daria Arbogast,Minden Collamore,Yasser Farra,Donn C. Young,Michael R. Grever +8 more
TL;DR: Depsipeptide was associated with a high number of potentially serious cardiac adverse events in patients with metastatic neuroendocrine tumor, and the risks for potentially life-threatening arrhythmia associated with this agent need to be comprehensively evaluated.
Journal Article
Blocking telomerase by dietary polyphenols is a major mechanism for limiting the growth of human cancer cells in vitro and in vivo
Imad Naasani,Fujiko Oh-hashi,Tomoko Oh-hara,Wan Yong Feng,Jeffrey N. Johnston,Kenneth Chan,Takashi Tsuruo +6 more
TL;DR: Clear in vitro and in vivo evidence is presented that the inhibition of the cancer-associated enzyme telomerase is a key mechanism involved in cancer inhibition by epigallocatechin gallate (EGCG), a major tea polyphenol.
Journal ArticleDOI
Phase 1 and pharmacodynamic studies of G3139, a Bcl-2 antisense oligonucleotide, in combination with chemotherapy in refractory or relapsed acute leukemia.
Guido Marcucci,John C. Byrd,Guowei Dai,Marko I. Klisovic,Peter J. Kourlas,Donn C. Young,Spero R. Cataland,Diane B. Fisher,David M. Lucas,Kenneth Chan,Pierluigi Porcu,Zhong-Pin Lin,Sherif F. Farag,Stanley R. Frankel,James A. Zwiebel,Eric H. Kraut,Stanley P. Balcerzak,Clara D. Bloomfield,Michael R. Grever,Michael A. Caligiuri +19 more
TL;DR: This study demonstrates that G3139 can be administered safely with FLAG chemotherapy and down-regulate its target, Bcl-2, and justifies the current plans for a phase 3 study in previously untreated high-risk AML.