K
Kenneth F. Wagner
Researcher at Walter Reed Army Institute of Research
Publications - 51
Citations - 2856
Kenneth F. Wagner is an academic researcher from Walter Reed Army Institute of Research. The author has contributed to research in topics: Population & Immune system. The author has an hindex of 25, co-authored 51 publications receiving 2794 citations. Previous affiliations of Kenneth F. Wagner include Naval Medical Center San Diego & Henry M. Jackson Foundation for the Advancement of Military Medicine.
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Journal ArticleDOI
Immunization with Envelope Subunit Vaccine Products Elicits Neutralizing Antibodies against Laboratory-Adapted but Not Primary Isolates of Human Immunodeficiency Virus Type 1
John R. Mascola,S W Snyder,Owen S. Weislow,S M Belay,R B Belshe,David H. Schwartz,M L Clements,Raphael Dolin,Barney S. Graham,Geoffrey J. Gorse,Michael C. Keefer,M J McElrath,Mary Clare Walker,Kenneth F. Wagner,John G. McNeil,Francine E. McCutchan,Donald S. Burke +16 more
TL;DR: There is a qualitative, or large quantitative, difference in the neutralizing antibody response induced by envelope subunit vaccination and natural HIV-1 infection, which is more susceptible to neutralization than are primary isolates cultured in human peripheral blood mononuclear cells.
Journal ArticleDOI
A Randomized Trial of Enhanced Therapy for Early Syphilis in Patients with and without Human Immunodeficiency Virus Infection
Robert T. Rolfs,M. Riduan Joesoef,Edward F. Hendershot,Anne Rompalo,Michael Augenbraun,Michael J. Chiu,Gail Bolan,Steven C. Johnson,Pamela French,Eric Steen,Justin D. Radolf,Sandra A. Larsen,William E. Brady,Kenneth F. Wagner,Debra A. D'Aquilante +14 more
TL;DR: After treatment for primary or secondary syphilis, the HIV-infected patients responded less well serologically than the patients without HIV infection, but clinically defined failure was uncommon in both groups.
Journal ArticleDOI
Antiviral Effect and Ex Vivo CD4+ T Cell Proliferation in HIV-Positive Patients as a Result of CD28 Costimulation
Bruce L. Levine,Joseph D. Mosca,James L. Riley,Richard G. Carroll,Maryanne Vahey,Linda L. Jagodzinski,Kenneth F. Wagner,Douglas L. Mayers,Donald S. Burke,Owen S. Weislow,Daniel C. St. Louis,Carl H. June +11 more
TL;DR: The CD28-mediated antiviral effect occurred early in the viral life cycle, before HIV-1 DNA integration, and may facilitate immune reconstitution and gene therapy approaches in persons with HIV infection.
Journal Article
Sources of variability in repeated T-helper lymphocyte counts from human immunodeficiency virus type 1-infected patients: total lymphocyte count fluctuations and diurnal cycle are important.
TL;DR: It is concluded that the large fluctuations that are observed in repeated CD4+ cell counts in HIV(+) patients can be explained in part by CD4- cell count diurnal cycle and in parts by high variability in total lymphocyte counts.
Journal ArticleDOI
Two Antigenically Distinct Subtypes of Human Immunodeficiency Virus Type 1: Viral Genotype Predicts Neutralization Serotype
John R. Mascola,Joost Louwagie,Francine E. McCutchan,Carrie L. Fischer,Patricia A. Hegerich,Kenneth F. Wagner,Arnold K. Fowler,John G. McNeil,Donald S. Burke +8 more
TL;DR: The existence of serotypes of HIV-1 suggests that a broadly effective vaccine may have to include strains from multiple subtypes, and future neutralization studies using primary isolates and multiple genotypes may be important for assessment ofAIDS antigenic diversity.