M
Michael C. Keefer
Researcher at University of Rochester
Publications - 124
Citations - 6423
Michael C. Keefer is an academic researcher from University of Rochester. The author has contributed to research in topics: Vaccination & HIV vaccine. The author has an hindex of 45, co-authored 121 publications receiving 5886 citations. Previous affiliations of Michael C. Keefer include University of Rochester Medical Center.
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Journal ArticleDOI
Efficacy Trial of a DNA/rAd5 HIV-1 Preventive Vaccine
Scott M. Hammer,Magdalena E. Sobieszczyk,Holly Janes,Shelly Karuna,Mark J. Mulligan,Doug Grove,Beryl A. Koblin,Susan Buchbinder,Michael C. Keefer,Georgia D. Tomaras,Nicole Frahm,John Hural,Chuka Anude,Barney S. Graham,Mary E. Enama,Elizabeth Adams,Edwin DeJesus,Richard M. Novak,Ian Frank,Carter Bentley,Shelly Ramirez,Rong Fu,Richard A. Koup,John R. Mascola,Gary J. Nabel,David C. Montefiori,James G. Kublin,M. Juliana McElrath,Lawrence Corey,Peter B. Gilbert +29 more
TL;DR: The DNA/rAd5 vaccine regimen did not reduce either the rate of HIV-1 acquisition or the viral-load set point in the population studied and had an acceptable side-effect profile.
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Immunization with Envelope Subunit Vaccine Products Elicits Neutralizing Antibodies against Laboratory-Adapted but Not Primary Isolates of Human Immunodeficiency Virus Type 1
John R. Mascola,S W Snyder,Owen S. Weislow,S M Belay,R B Belshe,David H. Schwartz,M L Clements,Raphael Dolin,Barney S. Graham,Geoffrey J. Gorse,Michael C. Keefer,M J McElrath,Mary Clare Walker,Kenneth F. Wagner,John G. McNeil,Francine E. McCutchan,Donald S. Burke +16 more
TL;DR: There is a qualitative, or large quantitative, difference in the neutralizing antibody response induced by envelope subunit vaccination and natural HIV-1 infection, which is more susceptible to neutralization than are primary isolates cultured in human peripheral blood mononuclear cells.
Journal ArticleDOI
Immune Responses to Human Immunodeficiency Virus (HIV) Type 1 Induced by Canarypox Expressing HIV-1MN gp120, HIV-1SF2 Recombinant gp120, or Both Vaccines in Seronegative Adults
Mary Lou Clements-Mann,Kent J. Weinhold,Thomas J. Matthews,Barney S. Graham,Geoffrey J. Gorse,Michael C. Keefer,M. Juliana McElrath,R H Hsieh,Jiri Mestecky,Susan Zolla-Pazner,John R. Mascola,David A. Schwartz,Robert F. Siliciano,Lawrence Corey,Peter F. Wright,Robert B. Belshe,Raphael Dolin,Susan A. Jackson,Serena Xu,Patricia E. Fast,Mary Clare Walker,Don Stablein,Jean-Louis Excler,James Tartaglia,Anne Marie Duliege,Faruk Sinangil,Enzo Paoletti +26 more
TL;DR: Neither vaccinia-immune status before vaccination nor ALVAC dose affected HIV immune responses, and trials with AlVAC expressing additional HIV components and rgp120 are underway.
Journal ArticleDOI
A Canarypox Vaccine Expressing Multiple Human Immunodeficiency Virus Type 1 Genes Given Alone or with Rgp120 Elicits Broad and Durable CD8+ Cytotoxic T Lymphocyte Responses in Seronegative Volunteers
Thomas G. Evans,Michael C. Keefer,Kent J. Weinhold,Mark Wolff,David C. Montefiori,Geoffrey J. Gorse,Barney S. Graham,M. Juliana McElrath,Mary Lou Clements-Mann,Mark J. Mulligan,Patricia E. Fast,Mary Clare Walker,Jean-Louis Excler,Ann-Marie Duliege,James Tartaglia +14 more
TL;DR: A strategy of immunization with a canarypox vector expressing multiple genes of HIV-1 given with gp120 results in durable CD8+ CTL responses to a broad range of epitopes.
Journal ArticleDOI
Diversion of HIV-1 vaccine–induced immunity by gp41-microbiota cross-reactive antibodies
Wilton B. Williams,Hua-Xin Liao,M. Anthony Moody,Thomas B. Kepler,S. Munir Alam,Feng Gao,Kevin Wiehe,Ashley M. Trama,Kathryn J. Jones,Ruijun Zhang,Hongshuo Song,Dawn J. Marshall,John F. Whitesides,Kaitlin Sawatzki,Axin Hua,Pinghuang Liu,Matthew Zirui Tay,Kelly E. Seaton,Xiaoying Shen,Andrew Foulger,Krissey E. Lloyd,Robert Parks,Justin Pollara,Guido Ferrari,Jae-Sung Yu,Nathan Vandergrift,David C. Montefiori,Magdalena E. Sobieszczyk,Scott M. Hammer,Shelly Karuna,Peter B. Gilbert,Doug Grove,Nicole Grunenberg,M. Juliana McElrath,John R. Mascola,Richard A. Koup,Lawrence Corey,Gary J. Nabel,Cecilia Morgan,Gavin J. Churchyard,Janine Maenza,Michael C. Keefer,Barney S. Graham,Lindsey R. Baden,Georgia D. Tomaras,Barton F. Haynes +45 more
TL;DR: The hypothesis that neonatal immunization with HIV-1 envelope may be able to imprint the B cell repertoire to respond to envelope antigenic sites that may otherwise be subdominant or disfavored is raised.