G
Geoffrey J. Gorse
Researcher at Saint Louis University
Publications - 81
Citations - 5491
Geoffrey J. Gorse is an academic researcher from Saint Louis University. The author has contributed to research in topics: Vaccination & Virus. The author has an hindex of 38, co-authored 78 publications receiving 5254 citations. Previous affiliations of Geoffrey J. Gorse include Veterans Health Administration.
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Journal ArticleDOI
Immunization with Envelope Subunit Vaccine Products Elicits Neutralizing Antibodies against Laboratory-Adapted but Not Primary Isolates of Human Immunodeficiency Virus Type 1
John R. Mascola,S W Snyder,Owen S. Weislow,S M Belay,R B Belshe,David H. Schwartz,M L Clements,Raphael Dolin,Barney S. Graham,Geoffrey J. Gorse,Michael C. Keefer,M J McElrath,Mary Clare Walker,Kenneth F. Wagner,John G. McNeil,Francine E. McCutchan,Donald S. Burke +16 more
TL;DR: There is a qualitative, or large quantitative, difference in the neutralizing antibody response induced by envelope subunit vaccination and natural HIV-1 infection, which is more susceptible to neutralization than are primary isolates cultured in human peripheral blood mononuclear cells.
Journal ArticleDOI
Effectiveness of live, attenuated intranasal influenza virus vaccine in healthy, working adults: a randomized controlled trial.
Kristin L. Nichol,Paul M. Mendelman,Kenneth P. Mallon,Lisa A. Jackson,Geoffrey J. Gorse,Robert B. Belshe,W. Paul Glezen,Janet Wittes +7 more
TL;DR: Intranasal trivalent LAIV vaccine was safe and effective in healthy, working adults in a year in which a drifted influenza A virus predominated, suggesting that LAIV provided substantial cross-protection against this variant influenza Airus strain.
Journal ArticleDOI
N95 respirators vs medical masks for preventing influenza among health care personnel: A randomized clinical trial
Lewis J. Radonovich,Michael S. Simberkoff,Michael S. Simberkoff,Mary T. Bessesen,Mary T. Bessesen,Alexandria C. Brown,Derek A. T. Cummings,Derek A. T. Cummings,Charlotte A. Gaydos,Jenna Los,Amanda Krosche,Amanda Krosche,Cynthia L. Gibert,Cynthia L. Gibert,Geoffrey J. Gorse,Geoffrey J. Gorse,Ann-Christine Nyquist,Ann-Christine Nyquist,Nicholas G. Reich,Maria C. Rodriguez-Barradas,Maria C. Rodriguez-Barradas,Connie S. Price,Connie S. Price,Trish M. Perl,Trish M. Perl +24 more
TL;DR: Among outpatient health care personnel, N95 respirators vs medical masks as worn by participants in this trial resulted in no significant difference in the incidence of laboratory-confirmed influenza.
Journal ArticleDOI
Immune Responses to Human Immunodeficiency Virus (HIV) Type 1 Induced by Canarypox Expressing HIV-1MN gp120, HIV-1SF2 Recombinant gp120, or Both Vaccines in Seronegative Adults
Mary Lou Clements-Mann,Kent J. Weinhold,Thomas J. Matthews,Barney S. Graham,Geoffrey J. Gorse,Michael C. Keefer,M. Juliana McElrath,R H Hsieh,Jiri Mestecky,Susan Zolla-Pazner,John R. Mascola,David A. Schwartz,Robert F. Siliciano,Lawrence Corey,Peter F. Wright,Robert B. Belshe,Raphael Dolin,Susan A. Jackson,Serena Xu,Patricia E. Fast,Mary Clare Walker,Don Stablein,Jean-Louis Excler,James Tartaglia,Anne Marie Duliege,Faruk Sinangil,Enzo Paoletti +26 more
TL;DR: Neither vaccinia-immune status before vaccination nor ALVAC dose affected HIV immune responses, and trials with AlVAC expressing additional HIV components and rgp120 are underway.
Journal ArticleDOI
A Canarypox Vaccine Expressing Multiple Human Immunodeficiency Virus Type 1 Genes Given Alone or with Rgp120 Elicits Broad and Durable CD8+ Cytotoxic T Lymphocyte Responses in Seronegative Volunteers
Thomas G. Evans,Michael C. Keefer,Kent J. Weinhold,Mark Wolff,David C. Montefiori,Geoffrey J. Gorse,Barney S. Graham,M. Juliana McElrath,Mary Lou Clements-Mann,Mark J. Mulligan,Patricia E. Fast,Mary Clare Walker,Jean-Louis Excler,Ann-Marie Duliege,James Tartaglia +14 more
TL;DR: A strategy of immunization with a canarypox vector expressing multiple genes of HIV-1 given with gp120 results in durable CD8+ CTL responses to a broad range of epitopes.