Kenneth L. Reed

TL;DR: Results from the lung histopathology component of the study indicated that pulmonary exposures to quartz particles produced dose-dependent inflammatory responses, concomitant with foamy alveolar macrophage accumulation and lung tissue thickening at the sites of normal particle deposition.

TL;DR: Comparisons of in vivo and in vitro measurements demonstrated little correlation, particularly when considering many of the variables assessed in this study-such as cell types to be utilized, culture conditions and time course of exposure, as well as measured end points.

TL;DR: In inhaled rutile ultrafine-TiO(2) particles are expected to have a low risk potential for producing adverse pulmonary health effects, and differences in responses to anatase/rutile uf-3 TiO( 2) particles versus the rutiles u-1 and u-2 TiO-2 particles could be related to crystal structure, inherent pH of the particles, or surface chemical reactivity.

TL;DR: The toxicity results of a base set of hazard tests on a set of newly developed, well-characterized, ultrafine TiO(2) (uf-TiO( 2)) particle-types demonstrated low hazard potential in mammals or aquatic species following acute exposures to the ultrafineTiO (2) particle- types tested in this program.

TL;DR: The results described herein provide the first example of nanoscale particle types which are not more cytotoxic or inflammogenic to the lung compared to larger sized particles of similar composition, and run counter to the postulation that surface area is a major factor associated with the pulmonary toxicity of nanoparticles.