Comparative pulmonary toxicity assessment of single-wall carbon nanotubes in rats.
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TLDR
Results from the lung histopathology component of the study indicated that pulmonary exposures to quartz particles produced dose-dependent inflammatory responses, concomitant with foamy alveolar macrophage accumulation and lung tissue thickening at the sites of normal particle deposition.About:
This article is published in Toxicological Sciences.The article was published on 2003-09-26 and is currently open access. It has received 1476 citations till now. The article focuses on the topics: Pulmonary toxicity & Bronchoalveolar lavage.read more
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References
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Journal ArticleDOI
Pulmonary Toxicity of Single-Wall Carbon Nanotubes in Mice 7 and 90 Days After Intratracheal Instillation
TL;DR: Results show that, for the test conditions described here and on an equal-weight basis, if carbon nanotubes reach the lungs, they are much more toxic than carbon black and can be more Toxic than quartz, which is considered a serious occupational health hazard in chronic inhalation exposures.
Journal ArticleDOI
Large-scale purification of single-wall carbon nanotubes: process, product, and characterization
Andrew G. Rinzler,Jie Liu,Hongjie Dai,Pavel Nikolaev,Chad B. Huffman,Fernando J. Rodríguez-Macías,Peter J. Boul,A.H. Lu,Dieter Heymann,Daniel T. Colbert,R. S. Lee,John E. Fischer,Apparao M. Rao,P. C. Eklund,Richard E. Smalley +14 more
TL;DR: A readily scalable purification process capable of handling single-wall carbon nanotube (SWNT) material in large batches, which should greatly facilitate investigation of material properties intrinsic to the nanotubes.
Journal ArticleDOI
Exposure to Carbon Nanotube Material: Assessment of Nanotube Cytotoxicity using Human Keratinocyte Cells
Anna A. Shvedova,Vincent Castranova,Elena R. Kisin,Diane Schwegler-Berry,Ashley R. Murray,Vadim Z Gandelsman,Andrew D. Maynard,Paul Baron +7 more
TL;DR: Investigation of adverse effects of single-wall carbon nanotubes using a cell culture of immortalized human epidermal keratinocytes indicates that dermal exposure to unrefined SWCNT may lead to dermal toxicity due to accelerated oxidative stress in the skin of exposed workers.
Journal ArticleDOI
Exposure to carbon nanotube material: aerosol release during the handling of unrefined single-walled carbon nanotube material
Andrew D. Maynard,Paul A. Baron,Michael Foley,Anna A. Shvedova,Elena R. Kisin,Vincent Castranova +5 more
TL;DR: Although laboratory studies indicated that with sufficient agitation, unrefined SWCNT material can release fine particles into the air, concentrations generated while handling material in the field were very low, and estimates of the airborne concen-tration of nanotube material generated during handling suggest that concentrations were lower than 53μg/m3 in all cases.
Journal ArticleDOI
Chronic Inhalation Exposure of Wistar Rats and two Different Strains of Mice to Diesel Engine Exhaust, Carbon Black, and Titanium Dioxide
U. Heinrich,Rainer Fuhst,Susanne Rittinghausen,Otto Creutzenberg,Bernd Bellmann,Wolfgang Koch,Karsten Levsen +6 more
TL;DR: In this paper, Wistar rats were exposed for two years to diesel engine exhaust, carbon black (Printex 90, Degussa, FR. G), and ultraline TiO2 (P25, P25, DEG), and were subsequently kept in clean air for 6 mo.
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