K
Kento Imajo
Researcher at Yokohama City University
Publications - 156
Citations - 4630
Kento Imajo is an academic researcher from Yokohama City University. The author has contributed to research in topics: Nonalcoholic fatty liver disease & Fatty liver. The author has an hindex of 28, co-authored 135 publications receiving 2949 citations.
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Journal ArticleDOI
Magnetic Resonance Imaging More Accurately Classifies Steatosis and Fibrosis in Patients With Nonalcoholic Fatty Liver Disease Than Transient Elastography
Kento Imajo,Takaomi Kessoku,Yasushi Honda,Wataru Tomeno,Yuji Ogawa,Hironori Mawatari,Koji Fujita,Masato Yoneda,Masataka Taguri,Hideyuki Hyogo,Yoshio Sumida,Masafumi Ono,Yuichiro Eguchi,Tomio Inoue,Takeharu Yamanaka,Koichiro Wada,Satoru Saito,Atsushi Nakajima +17 more
TL;DR: MRI-based noninvasive assessment of liver fibrosis and steatosis is a potential alternative to liver biopsy in clinical practice and magnetic resonance elastography and proton density fat fraction methods have higher diagnostic performance than TE and CAP methods.
Journal ArticleDOI
Hyperresponsivity to Low-Dose Endotoxin during Progression to Nonalcoholic Steatohepatitis Is Regulated by Leptin-Mediated Signaling
Kento Imajo,Koji Fujita,Masato Yoneda,Yuichi Nozaki,Yuji Ogawa,Yoshiyasu Shinohara,Shingo Kato,Hironori Mawatari,Wataru Shibata,Hiroshi Kitani,Kenichi Ikejima,Hiroyuki Kirikoshi,Noriko Nakajima,Satoru Saito,Shiro Maeyama,Sumio Watanabe,Koichiro Wada,Atsushi Nakajima +17 more
TL;DR: It is demonstrated that upregulation of CD14 by leptin-mediated signaling is critical to hyperreactivity against endotoxin during NASH progression, and a mechanism of bacteria-mediated progression of NASH is proposed.
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Magnetic Resonance vs Transient Elastography Analysis of Patients With Nonalcoholic Fatty Liver Disease: A Systematic Review and Pooled Analysis of Individual Participants.
Cynthia Hsu,Cyrielle Caussy,Cyrielle Caussy,Kento Imajo,Jun Chen,Siddharth Singh,Kellee Kaulback,Minh Le,Jonathan Hooker,Xin M. Tu,Ricki Bettencourt,Meng Yin,Claude B. Sirlin,Richard L. Ehman,Atsushi Nakajima,Rohit Loomba +15 more
TL;DR: A pooled analysis of data from individual participants with biopsy‐proven NAFLD found MRE to have a statistically significantly higher diagnostic accuracy than TE in detection of each stage of fibrosis.
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Involvement of a periodontal pathogen, Porphyromonas gingivalis on the pathogenesis of non-alcoholic fatty liver disease
Masato Yoneda,Shuhei Naka,Kazuhiko Nakano,Koichiro Wada,Hiroki Endo,Hironori Mawatari,Kento Imajo,Ryota Nomura,Kazuya Hokamura,Masafumi Ono,Shogo Murata,Iwai Tohnai,Yoshio Sumida,Toshihide Shima,Masae Kuboniwa,Kazuo Umemura,Yoshinori Kamisaki,Atsuo Amano,Takeshi Okanoue,Takashi Ooshima,Atsushi Nakajima +20 more
TL;DR: Infection with high-virulence P. gingivalis might be an additional risk factor for the development/progression of NAFLD/NASH and non-surgical periodontal treatments carried out for 3 months ameliorated the liver function parameters, such as the serum levels of AST and ALT.
Journal ArticleDOI
The Selective SGLT2 Inhibitor Ipragliflozin Has a Therapeutic Effect on Nonalcoholic Steatohepatitis in Mice
Yasushi Honda,Kento Imajo,Takayuki Kato,Takaomi Kessoku,Yuji Ogawa,Wataru Tomeno,Shingo Kato,Hironori Mawatari,Koji Fujita,Masato Yoneda,Satoru Saito,Atsushi Nakajima +11 more
TL;DR: The results suggest that ipragliflozin has a therapeutic effect on NASH with T2DM, and improve the pathogenesis of NASH by reducing insulin resistance and lipotoxicity in NASH-model mice.