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Yasushi Honda
Researcher at Yokohama City University
Publications - 52
Citations - 1900
Yasushi Honda is an academic researcher from Yokohama City University. The author has contributed to research in topics: Fatty liver & Nonalcoholic fatty liver disease. The author has an hindex of 15, co-authored 52 publications receiving 1152 citations.
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Journal ArticleDOI
Magnetic Resonance Imaging More Accurately Classifies Steatosis and Fibrosis in Patients With Nonalcoholic Fatty Liver Disease Than Transient Elastography
Kento Imajo,Takaomi Kessoku,Yasushi Honda,Wataru Tomeno,Yuji Ogawa,Hironori Mawatari,Koji Fujita,Masato Yoneda,Masataka Taguri,Hideyuki Hyogo,Yoshio Sumida,Masafumi Ono,Yuichiro Eguchi,Tomio Inoue,Takeharu Yamanaka,Koichiro Wada,Satoru Saito,Atsushi Nakajima +17 more
TL;DR: MRI-based noninvasive assessment of liver fibrosis and steatosis is a potential alternative to liver biopsy in clinical practice and magnetic resonance elastography and proton density fat fraction methods have higher diagnostic performance than TE and CAP methods.
Journal ArticleDOI
The Selective SGLT2 Inhibitor Ipragliflozin Has a Therapeutic Effect on Nonalcoholic Steatohepatitis in Mice
Yasushi Honda,Kento Imajo,Takayuki Kato,Takaomi Kessoku,Yuji Ogawa,Wataru Tomeno,Shingo Kato,Hironori Mawatari,Koji Fujita,Masato Yoneda,Satoru Saito,Atsushi Nakajima +11 more
TL;DR: The results suggest that ipragliflozin has a therapeutic effect on NASH with T2DM, and improve the pathogenesis of NASH by reducing insulin resistance and lipotoxicity in NASH-model mice.
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Palmitate-induced lipotoxicity is crucial for the pathogenesis of nonalcoholic fatty liver disease in cooperation with gut-derived endotoxin
Yuji Ogawa,Kento Imajo,Yasushi Honda,Takaomi Kessoku,Wataru Tomeno,Shingo Kato,Koji Fujita,Masato Yoneda,Satoru Saito,Yusuke Saigusa,Hideyuki Hyogo,Yoshio Sumida,Yoshito Itoh,Kosei Eguchi,Takeharu Yamanaka,Koichiro Wada,Atsushi Nakajima +16 more
TL;DR: A significant correlation between serum free fatty acid levels and liver fibrosis stage was observed in patients with NAFLD and results indicate that palmitate may play crucial roles in the pathogenesis ofNAFLD in the presence of gut-derived endotoxin.
Journal ArticleDOI
Pemafibrate, a novel selective peroxisome proliferator-activated receptor alpha modulator, improves the pathogenesis in a rodent model of nonalcoholic steatohepatitis
Yasushi Honda,Takaomi Kessoku,Yuji Ogawa,Wataru Tomeno,Kento Imajo,Koji Fujita,Masato Yoneda,Toshiaki Takizawa,Satoru Saito,Yoji Nagashima,Atsushi Nakajima +10 more
TL;DR: Pemafibrate is a novel selective peroxisome proliferator-activated receptor α modulator that can maximize the beneficial effects and minimize the adverse effects of fibrates used currently in NAFLD/NASH.
Journal ArticleDOI
Non-alcoholic fatty liver disease comorbid with major depressive disorder: The pathological features and poor therapeutic efficacy.
Wataru Tomeno,Keigo Kawashima,Keigo Kawashima,Masato Yoneda,Masato Yoneda,Satoru Saito,Yuji Ogawa,Yasushi Honda,Takaomi Kessoku,Kento Imajo,Hironori Mawatari,Koji Fujita,Yoshio Hirayasu,Atsushi Nakajima +13 more
TL;DR: The purpose of this study was to identify the clinical features of non‐alcoholic fatty liver disease patients comorbid with MDD and to investigate the influence of MDD on the effect of treatment in patients with NAFLD.