K
Kerry Kocher
Researcher at Massachusetts Institute of Technology
Publications - 4
Citations - 1184
Kerry Kocher is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Locus (genetics) & Population. The author has an hindex of 4, co-authored 4 publications receiving 1175 citations.
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Journal ArticleDOI
Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn disease.
John D. Rioux,Mark J. Daly,Mark S. Silverberg,Kerstin Lindblad,Hillary Steinhart,Zane Cohen,Terrye Delmonte,Kerry Kocher,Katie Miller,Sheila Guschwan,Edward J. Kulbokas,Sinéad B. O'Leary,Ellen Winchester,Ken Dewar,Todd Green,Valerie Stone,Christine S. Chow,Albert Cohen,Diane Langelier,Gilles Lapointe,Daniel Gaudet,Janet Faith,Nancy Branco,Shelley B. Bull,Robin S. McLeod,Anne M. Griffiths,Alain Bitton,Gordon R. Greenberg,Eric S. Lander,Katherine A. Siminovitch,Thomas J. Hudson,Thomas J. Hudson +31 more
TL;DR: This work seeks to design a systematic approach for LD mapping and applies it to the localization of a gene (IBD5) conferring susceptibility to Crohn disease, and binds the region to a common haplotype that shows strong association with the disease and contains the cytokine gene cluster.
Journal ArticleDOI
CARD15 genetic variation in a Quebec population: prevalence, genotype-phenotype relationship, and haplotype structure.
Severine Vermeire,Gary Wild,Kerry Kocher,Josee Cousineau,Line Dufresne,Alain Bitton,Diane Langelier,Pierre Paré,Gilles Lapointe,Albert Cohen,Mark J. Daly,John D. Rioux +11 more
TL;DR: Analysis of the relationship between genotype and phenotype convincingly demonstrates that CARD15 variants are significantly associated with ileal disease involvement, as opposed to strictly colonic disease (P<.001), and shows that CARD 15 involvement with CD is detectable by use of publicly available SNPs alone.
Journal ArticleDOI
Using a genome-wide scan and meta-analysis to identify a novel IBD locus and confirm previously identified IBD loci.
TL;DR: Meta-analysis of linkage data is a powerful approach for identifying and confirming common susceptibility loci and specifically shows that IBD1, IBD3, and IBD5 are the major, common IBD susceptibility loca in the populations studied thus far.
Journal ArticleDOI
Genomewide search and association studies in a Finnish celiac disease population: Identification of a novel locus and replication of the HLA and CTLA4 loci.
John D. Rioux,Hannele Karinen,Kerry Kocher,Sheila Guschwan McMahon,Päivi Kärkkäinen,E Janatuinen,Markku Heikkinen,Risto Julkunen,Jussi Pihlajamäki,Anita Naukkarinen,Veli-Matti Kosma,Mark J. Daly,Eric S. Lander,Markku Laakso +13 more
TL;DR: The aim of this study was to identify loci that contribute to disease susceptibility in a CD population from Finland and performed targeted typing and analyses that replicated the associations of the HLA and CTLA4 loci.