Z
Zane Cohen
Researcher at University of Toronto
Publications - 154
Citations - 9737
Zane Cohen is an academic researcher from University of Toronto. The author has contributed to research in topics: Familial adenomatous polyposis & Ulcerative colitis. The author has an hindex of 50, co-authored 151 publications receiving 9340 citations. Previous affiliations of Zane Cohen include Mount Sinai Hospital & Toronto General Hospital.
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Journal ArticleDOI
The Molecular Basis of Turcot's Syndrome
Stanley R. Hamilton,Bo Liu,Ramon Parsons,Nickolas Papadopoulos,Jin Jen,Steven M. Powell,Anne J. Krush,Theresa Berk,Zane Cohen,Bernard Têtu,Peter C. Burger,Patricia A. Wood,Fowzia Taqi,Susan V. Booker,Gloria M. Petersen,G. Johan A. Offerhaus,Anne C. Tersmette,Francis M. Giardiello,Bert Vogelstein,Kenneth W. Kinzler +19 more
TL;DR: The association between brain tumors and multiple colorectal adenomas can result from two distinct types of germ-line defects: mutation of the APC gene or mutation of a mismatch-repair gene.
Journal ArticleDOI
Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn disease.
John D. Rioux,Mark J. Daly,Mark S. Silverberg,Kerstin Lindblad,Hillary Steinhart,Zane Cohen,Terrye Delmonte,Kerry Kocher,Katie Miller,Sheila Guschwan,Edward J. Kulbokas,Sinéad B. O'Leary,Ellen Winchester,Ken Dewar,Todd Green,Valerie Stone,Christine S. Chow,Albert Cohen,Diane Langelier,Gilles Lapointe,Daniel Gaudet,Janet Faith,Nancy Branco,Shelley B. Bull,Robin S. McLeod,Anne M. Griffiths,Alain Bitton,Gordon R. Greenberg,Eric S. Lander,Katherine A. Siminovitch,Thomas J. Hudson,Thomas J. Hudson +31 more
TL;DR: This work seeks to design a systematic approach for LD mapping and applies it to the localization of a gene (IBD5) conferring susceptibility to Crohn disease, and binds the region to a common haplotype that shows strong association with the disease and contains the cytokine gene cluster.
Journal ArticleDOI
Genomewide search in Canadian families with inflammatory bowel disease reveals two novel susceptibility loci.
John D. Rioux,Mark S. Silverberg,Mark J. Daly,A. Hillary Steinhart,Robin S. McLeod,Anne M. Griffiths,Todd Green,Thomas Brettin,Valerie Stone,Shelley B. Bull,Alain Bitton,C. Noel Williams,Gordon R. Greenberg,Zane Cohen,Eric S. Lander,Thomas J. Hudson,Thomas J. Hudson,Katherine A. Siminovitch +17 more
TL;DR: A genomewide scan in 158 Canadian sib-pair families identified three regions of suggestive linkage and one region of significant linkage to 19p13 that contributes to CD susceptibility in families with early-onset disease.
Journal ArticleDOI
Reduction in Adhesive Small-Bowel Obstruction by Seprafilm® Adhesion Barrier After Intestinal Resection
Victor W. Fazio,Zane Cohen,James W. Fleshman,Harry van Goor,Joel J. Bauer,Bruce G. Wolff,Marvin L. Corman,Robert W. Beart,Steven D. Wexner,James M. Becker,John R. T. Monson,Howard S. Kaufman,David E. Beck,H. Randolph Bailey,Kirk A. Ludwig,Michael J. Stamos,Ara Darzi,Ronald Bleday,Richard Dorazio,Robert D. Madoff,Lee E. Smith,Susan L. Gearhart,Keith D. Lillemoe,Jonas Göhl +23 more
TL;DR: The overall bowel obstruction rate was unchanged; however, adhesive small-bowel obstruction requiring reoperation was significantly reduced by the use of Seprafilm®, which was the only factor that predicted this outcome.
Journal ArticleDOI
A prospective, randomized, multicenter, controlled study of the safety of Seprafilm adhesion barrier in abdominopelvic surgery of the intestine.
TL;DR: This study confirmed the safety of Seprafilm® adhesion barrier with respect to abdominal abscess, pelvicAbscess, and pulmonary embolism when administered to patients undergoing abdominopelvic surgery, and wrapped the suture or staple line of a fresh bowel anastomosis with Sepra film should be avoided.