D
Diane Langelier
Researcher at Centre Hospitalier Universitaire de Sherbrooke
Publications - 10
Citations - 1876
Diane Langelier is an academic researcher from Centre Hospitalier Universitaire de Sherbrooke. The author has contributed to research in topics: Single-nucleotide polymorphism & Inflammatory bowel disease. The author has an hindex of 9, co-authored 10 publications receiving 1831 citations. Previous affiliations of Diane Langelier include Université de Sherbrooke.
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Journal ArticleDOI
Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn disease.
John D. Rioux,Mark J. Daly,Mark S. Silverberg,Kerstin Lindblad,Hillary Steinhart,Zane Cohen,Terrye Delmonte,Kerry Kocher,Katie Miller,Sheila Guschwan,Edward J. Kulbokas,Sinéad B. O'Leary,Ellen Winchester,Ken Dewar,Todd Green,Valerie Stone,Christine S. Chow,Albert Cohen,Diane Langelier,Gilles Lapointe,Daniel Gaudet,Janet Faith,Nancy Branco,Shelley B. Bull,Robin S. McLeod,Anne M. Griffiths,Alain Bitton,Gordon R. Greenberg,Eric S. Lander,Katherine A. Siminovitch,Thomas J. Hudson,Thomas J. Hudson +31 more
TL;DR: This work seeks to design a systematic approach for LD mapping and applies it to the localization of a gene (IBD5) conferring susceptibility to Crohn disease, and binds the region to a common haplotype that shows strong association with the disease and contains the cytokine gene cluster.
Journal ArticleDOI
Common variants in the NLRP3 region contribute to Crohn's disease susceptibility
Alexandra-Chloé Villani,Mathieu Lemire,Geneviève Fortin,Edouard Louis,Mark S. Silverberg,Catherine Collette,Nobuyasu Baba,Cécile Libioulle,Jacques Belaiche,Alain Bitton,Daniel Gaudet,Albert Cohen,Diane Langelier,Paul R. Fortin,Joan E. Wither,Marika Sarfati,Paul Rutgeerts,John D. Rioux,Severine Vermeire,Thomas J. Hudson,Denis Franchimont,Denis Franchimont +21 more
TL;DR: Results suggest that the NLRP3 region is also implicated in the susceptibility of more common inflammatory diseases such as Crohn's disease, and this region is known to be responsible for three rare autoinflammatory disorders.
Journal ArticleDOI
CARD15 genetic variation in a Quebec population: prevalence, genotype-phenotype relationship, and haplotype structure.
Severine Vermeire,Gary Wild,Kerry Kocher,Josee Cousineau,Line Dufresne,Alain Bitton,Diane Langelier,Pierre Paré,Gilles Lapointe,Albert Cohen,Mark J. Daly,John D. Rioux +11 more
TL;DR: Analysis of the relationship between genotype and phenotype convincingly demonstrates that CARD15 variants are significantly associated with ileal disease involvement, as opposed to strictly colonic disease (P<.001), and shows that CARD 15 involvement with CD is detectable by use of publicly available SNPs alone.
Journal ArticleDOI
The role of the Toll receptor pathway in susceptibility to inflammatory bowel diseases
P. L. De Jager,Denis Franchimont,Alicja Waliszewska,Alain Bitton,Atika Cohen,Diane Langelier,Jacques Belaiche,Severine Vermeire,L. Farwell,An Goris,Cécile Libioulle,Niraj Jani,Themistocles Dassopoulos,Gillian Bromfield,Bernard Dubois,Judy H. Cho,S Brant,Richard H. Duerr,Huiying Yang,J. I. Rotter,Mark S. Silverberg,A H Steinhart,Mark J. Daly,Daniel K. Podolsky,Edouard Louis,David A. Hafler,John D. Rioux,John D. Rioux +27 more
TL;DR: Novel suggestive evidence that TIRAP has a modest effect on risk of IBD is described, which offers additional evidence that the TLR4 pathway – in this case,TLR4 and its signaling molecule T IRAP – plays a role in susceptibility to IBD.
Journal ArticleDOI
Genetic variation in the familial Mediterranean fever gene (MEFV) and risk for Crohn's disease and ulcerative colitis.
Alexandra-Chloé Villani,Mathieu Lemire,Edouard Louis,Mark S. Silverberg,Catherine Collette,Geneviève Fortin,Elaine R. Nimmo,Yannick Renaud,Sébastien Brunet,Cécile Libioulle,Jacques Belaiche,Alain Bitton,Daniel Gaudet,Albert Cohen,Diane Langelier,John D. Rioux,Ian D. Arnott,Gary Wild,Paul Rutgeerts,Jack Satsangi,Severine Vermeire,Thomas J. Hudson,Denis Franchimont,Denis Franchimont +23 more
TL;DR: The results suggest that common variants in the MEFV region do not contribute to CD and UC susceptibility and may be a consequence of distinct founder effects or of the relative small sample size of the cohorts evaluated in this study.