K
Kerstin Mock
Researcher at University of Freiburg
Publications - 6
Citations - 750
Kerstin Mock is an academic researcher from University of Freiburg. The author has contributed to research in topics: Metastasis & Epithelial–mesenchymal transition. The author has an hindex of 6, co-authored 6 publications receiving 601 citations. Previous affiliations of Kerstin Mock include University Medical Center Freiburg.
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Journal ArticleDOI
ZEB1 turns into a transcriptional activator by interacting with YAP1 in aggressive cancer types
Waltraut Lehmann,Dirk Mossmann,Julia Kleemann,Kerstin Mock,Chris Meisinger,Tilman Brummer,Ricarda Herr,Simone Brabletz,Marc P. Stemmler,Thomas Brabletz +9 more
TL;DR: A direct interaction of ZEB1 with the Hippo pathway effector YAP, but notably not with its paralogue TAZ is described, thereby linking two pathways with similar cancer promoting effects and is a predictor of poor survival, therapy resistance and increased metastatic risk in breast cancer.
Journal ArticleDOI
ZEB1-associated drug resistance in cancer cells is reversed by the class I HDAC inhibitor mocetinostat
Simone Meidhof,Simone Brabletz,Waltraut Lehmann,Bogdan-Tiberius Preca,Kerstin Mock,Manuel Ruh,Julia Schüler,Maria Berthold,Anika Weber,Ulrike Burk,Michael Lübbert,Michael Lübbert,Martin Puhr,Zoran Culig,Ulrich F. Wellner,Tobias Keck,Peter Bronsert,Simon Küsters,Ulrich T. Hopt,Marc P. Stemmler,Thomas Brabletz,Thomas Brabletz +21 more
TL;DR: The data encourage the application of mechanism‐based combinations of selected epigenetic drugs with standard chemotherapy for the rational treatment of aggressive solid tumors, such as pancreatic cancer.
Journal ArticleDOI
A self-enforcing CD44s/ZEB1 feedback loop maintains EMT and stemness properties in cancer cells.
Bogdan-Tiberius Preca,Bogdan-Tiberius Preca,Karolina Bajdak,Karolina Bajdak,Kerstin Mock,Kerstin Mock,Vignesh Sundararajan,Vignesh Sundararajan,Jessica Pfannstiel,Jochen Maurer,Jochen Maurer,Ulrich F. Wellner,Ulrich T. Hopt,Tilman Brummer,Tilman Brummer,Simone Brabletz,Simone Brabletz,Thomas Brabletz,Marc P. Stemmler,Marc P. Stemmler +19 more
TL;DR: A self‐enforcing feedback loop that employs CD44s to activate Z EB1 expression renders tumor cell stemness independent of external stimuli, as ZEB1 downregulates ESRP1, further promotingCD44s isoform synthesis.
Journal ArticleDOI
Zeb1 Regulates E-cadherin and Epcam (Epithelial Cell Adhesion Molecule) Expression to Control Cell Behavior in Early Zebrafish Development
TL;DR: Zeb1 fine-tunes E-cadherin- and Epcam-mediated cell adhesion to control cell behavior during gastrulation and segmentation stages and finds a similar ZEB1-dependent repression of EPCAM expression in human pancreatic and breast cancer cell lines.
Journal ArticleDOI
A novel ZEB1/HAS2 positive feedback loop promotes EMT in breast cancer
Bogdan-Tiberius Preca,Bogdan-Tiberius Preca,Karolina Bajdak,Kerstin Mock,Waltraut Lehmann,Vignesh Sundararajan,Peter Bronsert,Alexandra Matzge-Ogi,Véronique Orian-Rousseau,Simone Brabletz,Thomas Brabletz,Jochen Maurer,Jochen Maurer,Marc P. Stemmler +13 more
TL;DR: A novel autocrine mechanism how ZEB1 is accelerating EMT is found, which is an indicator of tumor cell-induced osteolysis that facilitates formation of bone metastasis.