S
Simone Brabletz
Researcher at University of Erlangen-Nuremberg
Publications - 33
Citations - 6084
Simone Brabletz is an academic researcher from University of Erlangen-Nuremberg. The author has contributed to research in topics: Metastasis & Epithelial–mesenchymal transition. The author has an hindex of 17, co-authored 29 publications receiving 5017 citations. Previous affiliations of Simone Brabletz include University Medical Center Freiburg & University of Freiburg.
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Journal ArticleDOI
The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs
Ulrich F. Wellner,Jörg Schubert,Ulrike Burk,Otto Schmalhofer,Feng Zhu,Annika G Sonntag,Bettina Waldvogel,Corinne Vannier,Douglas S. Darling,Axel zur Hausen,Valerie G. Brunton,Jennifer P. Morton,Owen J. Sansom,Julia Schüler,Marc P. Stemmler,Christoph Herzberger,Ulrich T. Hopt,Tobias Keck,Simone Brabletz,Thomas Brabletz +19 more
TL;DR: It is proposed that ZEB1 links EMT-activation and stemness-maintenance by suppressingstemness-inhibiting microRNAs (miRNAs) and thereby is a promoter of mobile, migrating cancer stem cells.
Journal ArticleDOI
E-cadherin, beta-catenin, and ZEB1 in malignant progression of cancer.
TL;DR: Mounting evidence indicates multiple reciprocal interactions of E-cadherin and β-catenin with EMT-inducing transcriptional repressors to stabilize an invasive mesenchymal phenotype of epithelial tumor cells.
Journal ArticleDOI
The ZEB/miR‐200 feedback loop—a motor of cellular plasticity in development and cancer?
Simone Brabletz,Thomas Brabletz +1 more
TL;DR: It is proposed that the ZEB/miR‐200 feedback loop is the molecular motor of cellular plasticity in development and disease, and in particular is a driving force for cancer progression towards metastasis by controlling the state of cancer stem cells.
Journal ArticleDOI
The EMT-activator Zeb1 is a key factor for cell plasticity and promotes metastasis in pancreatic cancer
Angela M. Krebs,Julia Mitschke,María Lasierra Losada,Otto Schmalhofer,Melanie Boerries,Melanie Boerries,Hauke Busch,Hauke Busch,Martin Boettcher,Dimitrios Mougiakakos,Wilfried Reichardt,Wilfried Reichardt,Peter Bronsert,Peter Bronsert,Valerie G. Brunton,Christian Pilarsky,Thomas Winkler,Simone Brabletz,Marc P. Stemmler,Thomas Brabletz +19 more
TL;DR: It is shown that different EMT-TFs have complementary subfunctions in driving pancreatic tumour metastasis, and that Depletion of Zeb1 suppresses stemness, colonization capacity and in particular phenotypic/metabolic plasticity of tumour cells, probably causing the observed in vivo effects.
Journal ArticleDOI
The ZEB1/miR-200 feedback loop controls Notch signalling in cancer cells.
Simone Brabletz,Karolina Bajdak,Simone Meidhof,Ulrike Burk,Gabriele Niedermann,Elke Firat,Ulrich F. Wellner,Arno Dimmler,Gerhard Faller,Jörg Schubert,Thomas Brabletz +10 more
TL;DR: It is shown that miR‐200 members target Notch pathway components, such as Jagged1 (Jag1) and the mastermind‐like coactivators Maml2 and Maml3, thereby mediating enhanced Notch activation by ZEB1, which explains increased Notch signalling in some types of cancers.