T
Tobias Keck
Researcher at University of Lübeck
Publications - 336
Citations - 8799
Tobias Keck is an academic researcher from University of Lübeck. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 42, co-authored 288 publications receiving 7165 citations. Previous affiliations of Tobias Keck include University of Southern California & Harvard University.
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Journal ArticleDOI
The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs
Ulrich F. Wellner,Jörg Schubert,Ulrike Burk,Otto Schmalhofer,Feng Zhu,Annika G Sonntag,Bettina Waldvogel,Corinne Vannier,Douglas S. Darling,Axel zur Hausen,Valerie G. Brunton,Jennifer P. Morton,Owen J. Sansom,Julia Schüler,Marc P. Stemmler,Christoph Herzberger,Ulrich T. Hopt,Tobias Keck,Simone Brabletz,Thomas Brabletz +19 more
TL;DR: It is proposed that ZEB1 links EMT-activation and stemness-maintenance by suppressingstemness-inhibiting microRNAs (miRNAs) and thereby is a promoter of mobile, migrating cancer stem cells.
Journal ArticleDOI
Efficacy of stapler versus hand-sewn closure after distal pancreatectomy (DISPACT): a randomised, controlled multicentre trial.
Markus K. Diener,Christoph M. Seiler,Inga Rossion,Jörg Kleeff,Matthias Glanemann,Giovanni Butturini,Ales Tomazic,Christiane J. Bruns,Olivier R. Busch,Stefan Farkas,Orlin Belyaev,John P. Neoptolemos,Christopher Halloran,Tobias Keck,Marco Niedergethmann,Klaus Gellert,Helmut Witzigmann,Otto Kollmar,Peter Langer,Ulrich Steger,Jens Neudecker,Frederik Berrevoet,Silke Ganzera,Markus M. Heiss,Steffen Luntz,Thomas Bruckner,Meinhard Kieser,Markus W. Büchler +27 more
TL;DR: Stapler closure did not reduce the rate of pancreatic fistula compared with hand-sewn closure for distal pancreatectomy and new strategies, including innovative surgical techniques, need to be identified to reduce this adverse outcome.
Journal ArticleDOI
The Lymph Node Ratio is the Strongest Prognostic Factor after Resection of Pancreatic Cancer
Hartwig Riediger,Tobias Keck,Ulrich F. Wellner,Axel zur Hausen,Ulrich Adam,Ulrich T. Hopt,Frank Makowiec +6 more
TL;DR: The routine estimation of the LN ratio may be helpful not only for the individual prediction of prognosis but also for the indication of adjuvant therapy and herein related outcome and therapy studies.
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Cancer cell invasion and EMT marker expression: a three-dimensional study of the human cancer-host interface.
Peter Bronsert,Kathrin Enderle-Ammour,Moritz Bader,Sylvia Timme,M Kuehs,Agnes Csanadi,Gian Kayser,Ilona Kohler,D Bausch,Jens Hoeppner,Ulrich T. Hopt,Tobias Keck,Elmar Stickeler,Bernward Passlick,Oliver Schilling,CP Reiss,Y Vashist,Thomas Brabletz,J. P. Berger,Johannes Lotz,Janine Olesch,Martin Werner,Ulrich F. Wellner +22 more
TL;DR: The relationship between current biological and clinical concepts such as cell migration modes, tumour budding and epithelial-mesenchymal transition (EMT) remains unclear in several aspects, especially for the'real' situation in human cancer as mentioned in this paper.
Journal ArticleDOI
Pancreatogastrostomy Versus Pancreatojejunostomy for RECOnstruction After PANCreatoduodenectomy (RECOPANC, DRKS 00000767) Perioperative and Long-term Results of a Multicenter Randomized Controlled Trial
Tobias Keck,Ulrich F. Wellner,Marcus Bahra,Fritz Klein,Olivia Sick,Marco Niedergethmann,Torsten J. Wilhelm,Stefan Farkas,T. Börner,Christiane Bruns,Axel Kleespies,Jörg Kleeff,André L. Mihaljevic,Waldemar Uhl,A. Chromik,Volker Fendrich,K. Heeger,Winfried Padberg,Andreas Hecker,Ulf P. Neumann,K. Junge,Jörg C. Kalff,Tim R. Glowka,Jens Werner,Phillip Knebel,Pompiliu Piso,M. Mayr,J. R. Izbicki,Yogesh K. Vashist,Peter Bronsert,Thomas Bruckner,Ronald Limprecht,Markus K. Diener,Inga Rossion,I. Wegener,U. T. Hopt +35 more
TL;DR: A multicenter prospective randomized controlled trial comparing pancreatogastrostomy (PG) versus pancreatojejunostomy (PJ) for reconstruction in pancreatoduodenectomy was conducted in this paper.