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Ketan S. Gajiwala
Researcher at Pfizer
Publications - 45
Citations - 4688
Ketan S. Gajiwala is an academic researcher from Pfizer. The author has contributed to research in topics: Hydrophobic effect & Structural genomics. The author has an hindex of 23, co-authored 45 publications receiving 3097 citations. Previous affiliations of Ketan S. Gajiwala include Texas A&M University.
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An oral SARS-CoV-2 Mpro inhibitor clinical candidate for the treatment of COVID-19.
Dafydd R. Owen,Charlotte Moira Norfor Allerton,Annaliesa S. Anderson,Lisa Aschenbrenner,Melissa Avery,Simon Berritt,Britton Boras,Rhonda D. Cardin,Anthony Carlo,Karen J. Coffman,Alyssa Dantonio,Li Di,Heather Eng,RoseAnn Ferre,Ketan S. Gajiwala,Scott A. Gibson,Samantha Elizabeth Greasley,Brett L. Hurst,Eugene P. Kadar,Amit S. Kalgutkar,Jack C. Lee,Jisun Lee,Wei Liu,Stephen W. Mason,Stephen Noell,Jonathan J. Novak,R. Scott Obach,Kevin Ogilvie,Nandini Chaturbhai Patel,Martin Pettersson,Devendra K. Rai,Matthew R. Reese,Matthew F. Sammons,Jean G. Sathish,Ravi Shankar P. Singh,Claire M. Steppan,Al E. Stewart,Jamison B. Tuttle,Lawrence W. Updyke,Patrick Robert Verhoest,Liuqing Wei,Qingyi Yang,Yuao Zhu +42 more
TL;DR: The worldwide outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome (SARS-CoV-2) has become a global pandemic as discussed by the authors.
Journal ArticleDOI
Forces contributing to the conformational stability of proteins
TL;DR: It is suggested that hydrogen bonding and the hydrophobic effect make large but comparable contributions to the stability of globular proteins.
Journal ArticleDOI
KIT kinase mutants show unique mechanisms of drug resistance to imatinib and sunitinib in gastrointestinal stromal tumor patients.
Ketan S. Gajiwala,Joseph Wu,James G. Christensen,Gayatri D. Deshmukh,Wade Diehl,Jonathan P DiNitto,Jessie M. English,Jessie M. English,Michael J. Greig,You-Ai He,Suzanne L. Jacques,Elizabeth A. Lunney,Michele McTigue,David Molina,Terri Quenzer,Peter A. Wells,Xiu Yu,Yan Zhang,Aihua Zou,Mark R. Emmett,Alan G. Marshall,Hui-Min Zhang,George D. Demetri +22 more
TL;DR: Results show that sunitinib targets the autoinhibited conformation of WT KIT and that the D816H mutant undergoes a shift in conformational equilibrium toward the active state, providing a structural and enzymologic explanation for the resistance profile observed with the KIT inhibitors.
Journal ArticleDOI
Contribution of Hydrophobic Interactions to Protein Stability
C. Nick Pace,Hailong Fu,Katrina Lee Fryar,John Landua,Saul R. Trevino,Bret A. Shirley,Marsha McNutt Hendricks,Satoshi Iimura,Ketan S. Gajiwala,J. Martin Scholtz,J. Martin Scholtz,Gerald R. Grimsley +11 more
TL;DR: The goal was to gain a better understanding of the contribution of hydrophobic interactions to protein stability, and to compare the results with those of previous studies.
Journal ArticleDOI
Contribution of hydrogen bonds to protein stability
C. Nick Pace,Hailong Fu,Katrina Lee Fryar,John Landua,Saul R. Trevino,D Schell,Richard L. Thurlkill,Satoshi Imura,J. Martin Scholtz,Ketan S. Gajiwala,Jozef Sevcik,Lubica Urbanikova,Jeffery K. Myers,Kazufumi Takano,Eric J. Hebert,Bret A. Shirley,Gerald R. Grimsley +16 more
TL;DR: The goal was to gain a better understanding of the contribution of the burial of polar groups and their hydrogen bonds to the conformational stability of proteins, and to compare the results with previous studies of similar mutants in other proteins.