M
Martin Pettersson
Researcher at Pfizer
Publications - 59
Citations - 2003
Martin Pettersson is an academic researcher from Pfizer. The author has contributed to research in topics: Gamma secretase & Amyloid precursor protein. The author has an hindex of 18, co-authored 59 publications receiving 956 citations. Previous affiliations of Martin Pettersson include University of Texas at Austin.
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An oral SARS-CoV-2 Mpro inhibitor clinical candidate for the treatment of COVID-19.
Dafydd R. Owen,Charlotte Moira Norfor Allerton,Annaliesa S. Anderson,Lisa Aschenbrenner,Melissa Avery,Simon Berritt,Britton Boras,Rhonda D. Cardin,Anthony Carlo,Karen J. Coffman,Alyssa Dantonio,Li Di,Heather Eng,RoseAnn Ferre,Ketan S. Gajiwala,Scott A. Gibson,Samantha Elizabeth Greasley,Brett L. Hurst,Eugene P. Kadar,Amit S. Kalgutkar,Jack C. Lee,Jisun Lee,Wei Liu,Stephen W. Mason,Stephen Noell,Jonathan J. Novak,R. Scott Obach,Kevin Ogilvie,Nandini Chaturbhai Patel,Martin Pettersson,Devendra K. Rai,Matthew R. Reese,Matthew F. Sammons,Jean G. Sathish,Ravi Shankar P. Singh,Claire M. Steppan,Al E. Stewart,Jamison B. Tuttle,Lawrence W. Updyke,Patrick Robert Verhoest,Liuqing Wei,Qingyi Yang,Yuao Zhu +42 more
TL;DR: The worldwide outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome (SARS-CoV-2) has become a global pandemic as discussed by the authors.
Journal ArticleDOI
Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19.
Britton Boras,Rhys M. Jones,Brandon J. Anson,Dan Arenson,Lisa Aschenbrenner,Malina A. Bakowski,Nathan Beutler,Joseph John Binder,Emily I. Chen,Heather Eng,Holly L. Hammond,Jennifer Hammond,Robert Haupt,Robert M. Hoffman,Eugene P. Kadar,Rob Kania,Emi Kimoto,Melanie G. Kirkpatrick,Lorraine F. Lanyon,Emma K. Lendy,Lillis Jonathan Richard,James Logue,Suman Luthra,Chunlong Ma,Stephen W. Mason,Marisa McGrath,Stephen Noell,R. Scott Obach,Matthew N O' Brien,Rebecca E. O’Connor,Kevin Ogilvie,Dafydd R. Owen,Martin Pettersson,Matthew R. Reese,Thomas F. Rogers,Thomas F. Rogers,Romel Rosales,Michelle Rossulek,Jean G. Sathish,Norimitsu Shirai,Claire M. Steppan,Martyn D. Ticehurst,Lawrence W. Updyke,Stuart Weston,Yuao Zhu,Kris M. White,Adolfo García-Sastre,Jun Wang,Arnab K. Chatterjee,Andrew D. Mesecar,Matthew B. Frieman,Annaliesa S. Anderson,Charlotte Moira Norfor Allerton +52 more
TL;DR: In this paper, a phosphate prodrug PF-07304814 was developed to inhibit coronavirus family 3CL protease activity with selectivity over human host protease targets.
Journal ArticleDOI
General strategy for the syntheses of corynanthe, tacaman, and oxindole alkaloids.
TL;DR: The total synthesis of the c Corynanthe alkaloid dihydrocorynantheol and the formal syntheses of the indole alkaloids tacamonine, rhynchophylline, and hirsutine are reported.
Journal ArticleDOI
γ-Secretase modulator (GSM) photoaffinity probes reveal distinct allosteric binding sites on presenilin.
Nikolay Pozdnyakov,Heather E. Murrey,Christina J. Crump,Christina J. Crump,Martin Pettersson,T. Eric Ballard,Christopher W. am Ende,Kwangwook Ahn,Kwangwook Ahn,Yue-Ming Li,Yue-Ming Li,Kelly R. Bales,Douglas S. Johnson +12 more
TL;DR: The photoaffinity probe E2012-BPyne specifically labels the N-terminal fragment of presenilin-1 (PS1-NTF) in cell membranes as well as in live cells and primary neuronal cultures providing evidence for multiple binding sites within γ-secretase that confer specific modulatory effects.
Posted ContentDOI
Discovery of a Novel Inhibitor of Coronavirus 3CL Protease as a Clinical Candidate for the Potential Treatment of COVID-19
Britton Boras,Rhys M. Jones,Brandon J. Anson,Dan Arenson,Lisa Aschenbrenner,Malina A. Bakowski,Nathan Beutler,Joseph John Binder,Emily I. Chen,Heather Eng,Jennifer Hammond,Robert M. Hoffman,Eugene P. Kadar,Robert Steven Kania,Emi Kimoto,Melanie G. Kirkpatrick,Lorraine F. Lanyon,Emma K. Lendy,Lillis Jonathan Richard,Suman Luthra,Chunlong Ma,Stephen Noell,R. Scott Obach,Kevin Ogilvie,Dafydd R. Owen,Martin Pettersson,Mattew R. Reese,Thomas F. Rogers,Thomas F. Rogers,Michelle Rossulek,Jean G. Sathish,Claire M. Steppan,Martyn D. Ticehurst,Lawrence W. Updyke,Yuao Zhu,Jun Wang,Arnab K. Chatterjee,Andrew D. Mesecar,Annaliesa S. Anderson,Charlotte Moira Norfor Allerton,Matthew B. Frieman,Stuart Weston,Marisa McGrath,James Logue,Robert Haupt,Holly L. Hammond,Stephen W. Mason,Norimitsu Shirai +47 more
TL;DR: The ADME, safety, in vitro, and in vivo antiviral activity data that supports the clinical evaluation of this compound as a potential COVID-19 treatment are presented.