K
Kevin A. Green
Researcher at University of Dundee
Publications - 17
Citations - 4365
Kevin A. Green is an academic researcher from University of Dundee. The author has contributed to research in topics: AMPK & Protein kinase A. The author has an hindex of 15, co-authored 17 publications receiving 4089 citations.
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Journal ArticleDOI
CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations
John W. Scott,Simon A. Hawley,Kevin A. Green,Miliea Anis,Greg Stewart,Gillian A. Scullion,David Norman,D. Grahame Hardie +7 more
TL;DR: T tandem pairs of CBS domains from AMP-activated protein kinase, IMP dehydrogenase-2, the chloride channel CLC2, and cystathionine beta-synthase bind AMP, ATP, or S-adenosyl methionine, while mutations that cause hereditary diseases impair this binding.
Journal ArticleDOI
Use of Cells Expressing γ Subunit Variants to Identify Diverse Mechanisms of AMPK Activation
Simon A. Hawley,Fiona A. Ross,Cyrille Chevtzoff,Kevin A. Green,Ashleigh Evans,Sarah Fogarty,Mhairi C. Towler,Laura J. E. Brown,Oluseye A. Ogunbayo,A. Mark Evans,D. Grahame Hardie +10 more
TL;DR: The authors' approaches distinguish at least six different mechanisms for AMPK activation and confirm that the widely used antidiabetic drug metformin activates AMPK by inhibiting mitochondrial respiration.
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The ancient drug salicylate directly activates AMP-activated protein kinase
Simon A. Hawley,Morgan D. Fullerton,Fiona A. Ross,Jonathan D. Schertzer,Cyrille Chevtzoff,Katherine J. Walker,Mark Peggie,Darya Zibrova,Kevin A. Green,Kirsty J. Mustard,Bruce E. Kemp,Kei Sakamoto,Gregory R. Steinberg,Gregory R. Steinberg,D. Grahame Hardie +14 more
TL;DR: The results suggest that AMPK activation could explain some beneficial effects of salsalate and aspirin in humans, and a possible molecular mechanism of action for a metabolite of aspirin is described.
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Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction
Kei Sakamoto,Afshan McCarthy,Darrin P. Smith,Kevin A. Green,D. Grahame Hardie,Alan Ashworth,Dario R. Alessi +6 more
TL;DR: These studies establish the importance of LKB1 in regulating AMPK activity and cellular energy levels in response to contraction and phenformin and reduce phosphorylation and activation of AMPKα2.
Journal ArticleDOI
Aspirin inhibits mTOR signaling, activates AMP-activated protein kinase, and induces autophagy in colorectal cancer cells.
Farhat V N Din,Asta Valanciute,Vanessa P. Houde,Daria Zibrova,Kevin A. Green,Kei Sakamoto,Dario R. Alessi,Malcolm G. Dunlop +7 more
TL;DR: Aspirin is an inhibitor of mTOR and an activator of AMPK, targeting regulators of intracellular energy homeostasis and metabolism, which could contribute to its protective effects against development of CRC.