M
Malcolm G. Dunlop
Researcher at University of Edinburgh
Publications - 347
Citations - 34451
Malcolm G. Dunlop is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Colorectal cancer & Cancer. The author has an hindex of 81, co-authored 322 publications receiving 30814 citations. Previous affiliations of Malcolm G. Dunlop include Edinburgh Royal Infirmary & Edinburgh Cancer Research Centre.
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Journal ArticleDOI
Telomere reduction in human colorectal carcinoma and with ageing
Nicholas D. Hastie,M. Dempster,Malcolm G. Dunlop,Alastair M. Thompson,Daryll K. Green,Robin C. Allshire,Robin C. Allshire +6 more
TL;DR: It is shown that in most of the colorectal carcinomas that were analysed, there is a reduction in the length of telomere repeat arrays relative to the normal colonic mucosa from the same patient, and it is proposed that the telomerase2–4 is inactive in somatic tissues, andTelomere length is an indicator of the number of cell divisions that it has taken to form a particular tissue and possibly to generate tumours.
Journal ArticleDOI
Mutations of two PMS homologues in hereditary nonpolyposis colon cancer.
Nicholas C. Nicolaides,Nickolas Papadopoulos,Bo Liu,Ying Fei Weit,Kenneth C. Carter,Steven M. Ruben,Craig A. Rosen,William A. Haseltine,Robert D. Fleischmann,Claire M. Fraser,Mark Raymond Adams,J. Craig Venter,Malcolm G. Dunlop,Stanley R. Hamilton,Gloria M. Petersen,Albert de la Chapelle,Bert Vogelstein,Kenneth W. Kinzler +17 more
TL;DR: Two additional homologues of the prokaryotic mutL gene were found to be mutated in the germline of HNPCC patients, which doubles the number of genes implicated in H NPCC and may help explain the relatively high incidence of this disease.
Journal ArticleDOI
Modulation of genetic associations with serum urate levels by body-mass-index in humans
Jennifer E. Huffman,Eva Albrecht,Alexander Teumer,Massimo Mangino,Karen Kapur,Toby Johnson,Z. Kutalik,Nicola Pirastu,Giorgio Pistis,Lorna M. Lopez,Toomas Haller,Perttu Salo,Anuj Goel,Man Li,Toshiko Tanaka,Abbas Dehghan,Daniela Ruggiero,Giovanni Malerba,Albert V. Smith,Ilja M. Nolte,Laura Portas,Amanda Phipps-Green,Lora Boteva,Pau Navarro,Åsa Johansson,Andrew A. Hicks,Ozren Polasek,Tõnu Esko,John F. Peden,Sarah E. Harris,Federico Murgia,Sarah H. Wild,Albert Tenesa,Adrienne Tin,Evelin Mihailov,Anne Grotevendt,Gauti Kjartan Gislason,Josef Coresh,Pio D'Adamo,Sheila Ulivi,Peter Vollenweider,Gérard Waeber,Susan Campbell,Ivana Kolcic,Krista Fisher,Margus Viigimaa,Jeffrey Metter,Corrado Masciullo,Elisabetta Trabetti,Cristina Bombieri,Rossella Sorice,Angela Doering,Eva Reischl,Konstantin Strauch,Albert Hofman,André G. Uitterlinden,Melanie Waldenberger,H-Erich Wichmann,Gail Davies,Alan J. Gow,Nicola Dalbeth,Lisa K. Stamp,Johannes H. Smit,Mirna Kirin,Ramaiah Nagaraja,Matthias Nauck,Claudia Schurmann,Kathrin Budde,Susan M. Farrington,Evropi Theodoratou,Antti Jula,Veikko Salomaa,Cinzia Sala,Christian Hengstenberg,Michel Burnier,R Maegi,Norman Klopp,Stefan Kloiber,Sabine Schipf,Samuli Ripatti,Stefano Cabras,Nicole Soranzo,Georg Homuth,Teresa Nutile,Patricia B. Munroe,Nicholas D. Hastie,Harry Campbell,Igor Rudan,Claudia P. Cabrera,Chris Haley,Oscar H. Franco,Tony R. Merriman,Vilmundur Gudnason,Mario Pirastu,Brenda W.J.H. Penninx,Brenda W.J.H. Penninx,Harold Snieder,Andres Metspalu,Marina Ciullo,Peter P. Pramstaller,Cornelia M. van Duijn,Luigi Ferrucci,Giovanni Gambaro,Ian J. Deary,Malcolm G. Dunlop,James F. Wilson,Paolo Gasparini,Ulf Gyllensten,Tim D. Spector,Alan F. Wright,Caroline Hayward,Hugh Watkins,Markus Perola,Murielle Bochud,W. H. Linda Kao,Mark J. Caulfield,Daniela Toniolo,Henry Voelzke,Christian Gieger,Anna Koettgen,Veronique Vitart +120 more
TL;DR: Interactions between body mass index (BMI) and common genetic variants affecting serum urate levels, genome-wide, and regression-type analyses in a non BMI-stratified overall sample suggested a role for N-glycan biosynthesis as a prominent urate-associated pathway in the lean stratum.
Journal ArticleDOI
British Society of Gastroenterology consensus guidelines on the management of inflammatory bowel disease in adults
Christopher A. Lamb,Christopher A. Lamb,Nicholas A. Kennedy,Tim Raine,P Hendy,P Hendy,Philip J Smith,Jimmy K. Limdi,Jimmy K. Limdi,Bu'Hussain Hayee,Bu'Hussain Hayee,Miranda Lomer,Miranda Lomer,Gareth Parkes,Gareth Parkes,Christian P. Selinger,Christian P. Selinger,Kevin Barrett,R Justin Davies,Cathy Bennett,Stuart Gittens,Malcolm G. Dunlop,Malcolm G. Dunlop,Omar Faiz,Aileen Fraser,Vikki Garrick,Paul D Johnston,Miles Parkes,Jeremy D. Sanderson,Jeremy D. Sanderson,Helen Terry,Daniel R. Gaya,Daniel R. Gaya,Tariq Iqbal,Tariq Iqbal,Stuart A. Taylor,Stuart A. Taylor,Melissa A. Smith,Melissa A. Smith,Matthew J Brookes,Richard Hansen,A Barney Hawthorne +41 more
TL;DR: Comprehensive up-to-date guidance is provided regarding indications for, initiation and monitoring of immunosuppressive therapies, nutrition interventions, pre-, peri- and postoperative management, as well as structure and function of the multidisciplinary team and integration between primary and secondary care.
Journal ArticleDOI
Guidelines for colorectal cancer screening and surveillance in moderate and high risk groups (update from 2002)
Stuart Cairns,John H. Scholefield,Robert Steele,Malcolm G. Dunlop,Huw Thomas,Gareth Evans,Jayne Eaden,Matthew D. Rutter,Wendy P Atkin,Brian P. Saunders,Anneke Lucassen,Paul Jenkins,Peter D. Fairclough,Christopher R J Woodhouse,Ireland +14 more
TL;DR: Advice on the appropriateness, method and frequency of screening for people at moderate and high risk from colorectal cancer and for those with inflammatory bowel disease is provided.